Call for Papers

RNA Therapeutics for Tissue Engineering


Guest Editors:

Elizabeth R. Balmayor, PhD
Assistant Professor of Trauma Surgery
Technical University of Munich, Munich, Germany

Christopher H. Evans, PhD, DSc
Director, Rehabilitation Medicine Research Center
Mayo Clinic, Rochester, USA

Increasing attention is being paid to the use of RNA molecules as agents of tissue engineering and regenerative medicine. Two main methodologies have been described, in which protein expression is either selectively suppressed or induced by specific types of RNA molecules. RNA interference (RNAi) using small, non-coding RNA molecules, microRNA and small interfering RNA, suppresses gene expression very efficiently in a highly specific manner. Conversely, messenger RNAs (mRNAs) introduced into the cell induce synthesis of their encoded proteins.

This approach holds several advantages over traditional DNA-based gene therapy including improved cell internalization and higher transfection efficiencies, without disruption of the host genome. In the context of tissue engineering and regenerative medicine, the eventual turnover of the exogenous RNA is a further advantage. Because conventional RNAs have strong immunogenicity and low stability, chemical modifications are needed to facilitate their therapeutic application. Moreover, efficient delivery systems are of crucial importance for efficient cell internalization.

In this special issue, “RNA Therapeutics for Tissue Engineering”, to be published in 2018, Guest Editors Elizabeth R. Balmayor, PhD and Christopher H. Evans, PhD seek high-quality research papers on the recent progress on RNA therapeutics with a focus on tissue engineering and regenerative medicine applications.

Topics of interest include, but are not limited to:

  • Chemical modifications to improve RNA stability and pharmacokinetic properties
  • RNA delivery
  • Nanoparticle-based delivery systems
  • Magnetofection and other physical means to improve RNA internalization
  • Regeneration of tissues, including cardiovascular, neural, pulmonary, and musculoskeletal by RNA transfer

Contributions will receive prompt and thorough peer review and will be published online (epub) ahead of print after acceptance. Please refer to our Instructions for Authors before submitting your manuscript for consideration.

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Tissue Engineering
, the official journal of TERMIS, is a distinguished biomedical journal that advances the field of tissue engineering and regenerative medicine by publishing high-impact research and applications on all aspects of tissue growth and regeneration. Multidisciplinary in scope, the journal brings together the principles of engineering and life sciences in tissue development and regenerative medicine. The Journal provides a central forum for groundbreaking scientific research and developments of clinical applications from leading experts in the field.

Advantages of publishing in Tissue Engineering include:

  • Rapid, high-quality peer review
  • Open Access options available
  • Fast and user-friendly electronic submission
  • Maximum exposure: accessible in 170 countries worldwide
  • New end-to-end Author Benefits Program

Learn More about this journal

Deadline for Manuscript Submission:
October 20, 2017

SUBMIT YOUR
MANUSCRIPT

For questions, please contact
Dr. Balmayor and Dr. Evans