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Contact: Vicki Cohn, (914) 740-2156, vcohn@liebertpub.com
Improving Stem Cell Transplantation Techniques to Promote Bone Repair

New Rochelle, NY, June 27, 2006—The success of tissue engineering strategies for bone repair that involve injecting stem cells into biocompatible, 3D fibrin matrices and then transplanting the scaffolds at the site of bone injury depend to a large extent on the concentration of the fibrinogen formulation used to prepare the scaffold and the structure of the clot that forms, according to a report in the June (Volume 12, Number 6) issue of Tissue Engineering, a peer-reviewed journal published by Mary Ann Liebert, Inc. The paper is available free online at www.liebertpub.com/ten.

            Wendy Ho, BSc, Bill Tawil, PhD, James Dunn, MD, PhD, and Benjamin Wu, DDS, PhD, from the UCLA School of Engineering, School of Medicine, and School of Dentistry, and from Baxter Healthcare Corporation reported that the fibrinogen solution used to manufacture a fibrin-based cell delivery system has a greater effect on the proliferation of human mesenchymal stem cells (hMSC) than does the thrombin component of the fibrin matrix. Furthermore, dilute fibrinogen solutions promote greater hMSC growth and differentiation and yield more open, homogeneous 3D fibrin clot structures, according to the findings presented in “The Behavior of Human Mesenchymal Stem Cells in 3D Fibrin Clots: Dependence on Fibrinogen Concentration and Clot Structure.”

            “The development of optimal delivery systems for stem cells, as demonstrated in this study is of great importance to all tissue engineers” says Peter C. Johnson, M.D., President and CEO of Scintellix, LLC and Co-Editor in Chief of Tissue Engineering.

            Successful bone repair using mesenchymal stem cell transplants requires creating a tissue environment conducive to stem cell proliferation and differentiation into the various mature cell types needed to form new bone. Researchers working to optimize bone engineering techniques are experimenting with different fibrin formulations to identify the optimal cell delivery system to support cell vigor and function and to promote bone healing.