Intensive Insulin Therapy after Brain Injury Is Not More Beneficial Than Conventional Therapy
New Rochelle, NY, July 12, 2011-Brain-injured patients treated with intensive insulin therapy (IIT) to control increased blood sugar levels do not have better neurological or mortality outcomes compared to those treated with conventional, less intensive insulin therapy (CIT), according to an article published in Journal of Neurotrauma, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online.
Although IIT did not improve the risk of early or late death following brain injury and did have a beneficial effect on long-term neurological recovery, it was associated with decreased infection rates, as described in the article, "Intensive Insulin Therapy in Brain Injury-a Meta-Analysis."
The meta-analysis of nine published randomized controlled trials, totaling 1,160 patients, was performed by a team of authors that included Syed Nabeel Zafar, MD, MPH, Aga Khan University (Karachi, Pakistan), Aftab Iqbal, MD, MS (Naya Jeevan, Karachi, Pakistan), Mauricio Farez, MD, MPH, Institute for Neurological Research, Raúl Carrea (Buenos Aires, Argentina), Suyog Kamatkar, MD, MS (Massachusetts Board of Registration in Medicine, Boston), and Marc de Moya, MD (Massachusetts General Hospital, Boston).
Journal of Neurotrauma is an authoritative peer-reviewed journal published monthly in print and online that focuses on the latest advances in the clinical and laboratory investigation of traumatic brain and spinal cord injury. Emphasis is on the basic pathobiology of injury to the nervous system, and the papers and reviews evaluate preclinical and clinical trials targeted at improving the early management and long-term care and recovery of patients with traumatic brain injury. Journal of Neurotrauma is the Official Journal of the National Neurotrauma Society and the International Neurotrauma Society. Complete tables of content and a free sample issue may be viewed online.