News & Events

For Immediate Release

Bookmark & Share
Contact: Kathryn Ryan, 914-740-2100,
What Types of Hydrogel Fillers Best Promote Functional Recovery in Nerve Regeneration?

New Rochelle, NY, August 11, 2016—Methods to improve nerve regeneration using nerve conduits filled with hydrogels can differ significantly in their ability to promote functional recovery depending on the porosity of the conduit and the bioactivity of the hydrogel, according to a new study published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until September 9, 2016.

Mindy Ezra, PhD, Jared Bushman, PhD, David Shreiber, PhD, Melitta Schachner, PhD, and Joachim Kohn, PhD, Rutgers, The State University of New Jersey (Piscataway) and Shantou University Medical College (Shantou, China), compared nerve regeneration in a mouse model of a 5-mm femoral nerve injury using porous or nonporous conduits containing collagen-only or enhanced collagen fillers. Only one form of enhanced collagen led to significant improvement in a measure of functional recovery. Furthermore, the degree of conduit porosity affected the hydrogels' ability to promote nerve regeneration, concluded the researchers in the article entitled "Porous and Nonporous Nerve Conduits: The Effects of a Hydrogel Luminal Filler With and Without a Neurite-Promoting Moiety."

“Nerve gaps after trauma or extirpative surgery normally require the harvest of sensory nerves elsewhere in the body, with associated morbidity," says Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC. “Progress in the development of synthetic conduits capable of guiding nerve regeneration – as in this study - have the potential to obviate this need."

Research reported in this publication was supported by the National Resource for Polymeric Biomaterials under NIH Award Number EB001046. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.