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Human Gene Therapy

Editor-in-Chief: Terence R. Flotte, MD
Deputy Editor, Europe: Thierry VandenDriessche, PhD
Deputy Editor, U.S.: Barry J. Byrne, MD, PhD
Human Gene Therapy Editor: Guangping Gao, PhD
Methods Editor: Hildegard Büning, PhD
Clinical Development Editor: James M. Wilson, MD, PhD

ISSN: 1043-0342 • Online ISSN: 1557-7422 • Published 22 issues annually

Current Volume: 27

Latest Impact Factor* is 3.755

*2014 Journal Citation Reports® published by Thomson Reuters, 2015

Human Gene Therapy Methods Latest Impact Factor* 2.436
*2014 Journal Citation Reports®
published by Thomson Reuters, 2015

Featured Press Releases and Editorial Content

  • Does AAV-Based Gene Delivery Cause Liver Cancer? The Debate Heats Up...Read More
  • Junction Opening Protein Boosts Cancer-Killing Effect of Oncolytic Virus...Read More
  • What Can We Learn From Zebrafish About Human Blood Disorders?...Read More
  • Progress and Promise of Gene Transfer and Gene Editing To Cure Beta-Thalassemias...Read More
  • Newly Identified Host Defense Mechanism Protects Cells From Viral Infection...Read More
  • Promising Results Reported in Study of AAV-based Gene Delivery to Treat Methylmalonic Acidemia...Read More
  • Major Advances and Ongoing Challenges for Gene Therapy in SCID-X1...Read More
  • Non-integrating Viral Vector Successfully Delivers Chemotherapy-Sensitizing Gene to Pancreatic Cancer Cells...Read More
  • Update on Advances in Gene Therapy From National Center for Advancing Translational Sciences...Read More
  • Can Gene Therapy Provide a Breakthrough in Alzheimer's Disease?...Read More
  • Proposed Link Between Liver Cancer and Adeno-Associated Virus Challenged...Read More
  • Discovering the Secret to Success and Innovation in Commercializing Biotechnology...Read More
  • Is The First Commercial Gene Therapy Product Within Sight?...Read More
  • Alternative Strategy for Gene Replacement Shows Promise in Duchenne Muscular Dystrophy...Read More
  • Gene Therapy Fully Restores Vision in Mouse Model of Leber Congenital Amaurosis...Read More
  • Optimizing Effectiveness of CAR T Cell Therapy in Lymphoma Highlighted in Special Nordic Issue of Human Gene Therapy...Read More
  • CRISPR-Based Genome Editing Technologies Poised to Revolutionize Medicine and Industry...Read More
  • New Techniques Improve Specificity of CRISPR/Cas9 Genome Editing Tools...Read More
  • Presidents of National Academy of Medicine and National Academy of Sciences Present New Initiative on Ethics of Human Gene Editing Technology...Read More
  • New Gene Editing Tools Force Renewed Debate Over Therapeutic Germline Alteration...Read More
  • Terry Flotte, MD Appointed New Editor-in-Chief of Human Gene Therapy...Read More
  • Gene Therapy Pioneers Richard C. Mulligan and A. Dusty Miller Reflect on Their Groundbreaking Discoveries...Read More
  • Pioneer Award Winners Katherine High, Amit Nathwani, Arthur Nienhuis, and Andrew Davidoff Honored for Advances in Hemophilia Gene Therapy
          - Read the Perspective by Dr. High  
          - Read the Perspective by Drs. Nathwani, Nienhuis, and Davidoff
  • Pioneer Award Recipients Zelig Eshhar, PhD and Carl H. June, MD, PhD Honored for Their Research on T-Cell Engineering for Cancer Immunotherapy
          - Read the Perspective by Dr. Eshhar 
          - Read the Perspective by Dr. June
  • Long-term Treatment Success Using Gene Therapy to Correct a Lethal Metabolic Disorder ...Read More
  • Pioneer Award Recipients Robin Ali, PhD, Jean Bennett, MD, PhD, and William Hauswirth, PhD, Honored for Their Research on Gene Therapy in Eye Disorders      
          - Read the Perspective by Dr. Bennett 
          - Read the Perspective by Dr. Hauswirth
  • Malcolm K. Brenner, MD, PhD Receives Pioneer Award for Advances in Gene-Modified T Cells Targeting Cancer...Read More
  • Splice-Switching Oligonucleotide Therapeutics Is Promising New Method for Editing Gene Transcripts...Read More
  • Christof von Kalle, MD, PhD Receives Pioneer Award for Contributions to Efficient Vector Integration in Human Gene Therapy...Read More
  • Frederic Bushman, PhD Receives Pioneer Award for Advancing Therapeutic Gene Delivery Methods...Read More
  • Gene Therapy Extends Survival in an Animal Model of Spinal Muscular Atrophy...Read More
  • Novel RNAi Therapy Silences Mutated Huntington's Disease Gene and Reduces Symptoms...Read More
  • James Wilson, MD, PhD Receives Pioneer Award for Research on Gene Therapy and AAV Gene Delivery Systems...Read Now
  • Pioneer Award Recipients Marina Cavazzana and Adrian Thrasher Recognized for Advancing Gene Therapy to the Clinic for Immunodeficiency Disorders...Read Now
  • Gene Therapy for Lysosomal Storage Disease Shown to Be Safe and Well Tolerated, with Promising Results...Read Now
  • Exclusive David Gancberg Article in Human Gene Therapy on European Commission Funding 2014–2015...Read Now
  • Joseph Glorioso, PhD, Receives Pioneer Award  for Engineering Herpes Simplex Virus Gene Delivery Systems...Read Now
  • Ronald Crystal, MD, Receives Pioneer Award for Developing First In Vivo Adenoviral Gene Delivery Vector...Read Now
  • Top 12 Pioneer Awards for Seminal Work in Gene and Cell Therapy Selected by Blue Ribbon Panel; Essays to be Published in Human Gene Therapy...Read Now
  • Special Tribute Issue for Sonia Skarlatos, PhD


Human Gene Therapy is the premier, multidisciplinary journal covering all aspects of gene therapy. The Journal publishes in-depth coverage of DNA, RNA, and cell therapies by delivering the latest breakthroughs in research and technologies. Human Gene Therapy provides a central forum for scientific and clinical information, including ethical, legal, regulatory, social, and commercial issues, which enables the advancement and progress of therapeutic procedures leading to improved patient outcomes, and ultimately, to curing diseases.

The Journal is divided into three parts. Human Gene Therapy, the flagship, is published 12 times per year. HGT Methods, a bimonthly journal, focuses on the applications of gene therapy to product testing and development. HGT Clinical Development, a quarterly journal, serves as a venue for publishing data relevant to the regulatory review and commercial development of cell and gene therapy products.

Complete HGT Program coverage includes:

  • Improvements in vector developments
  • Delivery systems
  • Cell therapy
  • Small nucleic acid therapeutics, including RNAi
  • Clinical trials and animal models
  • Clinical protocols
  • Pre-clinical animal and in vitro studies to assess the safety of gene and cell therapy products used to support clinical applications
  • Clinical trials including those in which the results are confirmatory or negative
  • Topical issues related to the commercial development of gene and cell therapy products

Human Gene Therapy was voted one of the most influential journals in Biology and Medicine over the last 100 years by the Biomedical & Life Sciences Division of the Special Libraries Association.

Human Gene Therapy, HGT Methods, and HGT Clinical Development are under the editorial leadership of Editor-in-Chief Terence R. Flotte, MD, University of Massachusetts Medical School; Deput Editor Europe Thierry VandenDriessche, PhD, Free University of Brussels (VUB); Deputy Editor U.S. Barry J. Byrne, MD, PhD, Powell Gene Therapy Center, University of Florida, College of Medicine; Human Gene Therapy Editor Guangping Gao, PhD, University of Massachusetts Medical School; Methods Editor Hildegard Büning, PhD, University of Cologne; Clinical Development Editor James M. Wilson, MD, PhD, University of Pennsylvania School of Medicine, Gene Therapy Program; and other leading investigators. View the entire editorial board.

Audience: Geneticists, medical geneticists, molecular biologists, virologists, experimental researchers, and experimental medicine specialists, among others.

Human Gene Therapy and HGT Methods provide “Instant Online” publication 72 hours after acceptance

This subscription includes:

Read Online

Editor-in-Chief: Terence R. Flotte, MD
ISSN: 1043-0342 • Monthly • Online ISSN: 1557-7422
Editorial Board   •   Author Information   •   Subscribe

Human Gene Therapy is the definitive peer-reviewed rapid-publication journal covering all aspects of human gene therapy.  The Journal publishes scientific papers on original investigations into the transfer and expression of genes in mammals, including humans with in-depth coverage of DNA, RNA, and cell therapies. Improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, are covered. 

Read Online

Editor-in-Chief: Terence R. Flotte, MD
ISSN: 1946-6536  • Bimonthly  •  Online ISSN: 1946-6544
Editorial Board  •   Author Information  •  Subscribe

Human Gene Therapy Methods (HGT Methods) publishes technological advances in cell and gene therapy that promote the development of gene therapy products into successful therapeutics. The Journal breaks new ground as the first to exclusively focus on the applications of gene therapy to product testing and development.

Read Online

Editor-in-Chief: Terence R. Flotte, MD
ISSN: 1043-0342  • Quarterly  •  Online ISSN: 1557-7422
Editorial Board  •   Author Information  •  Subscribe

Human Gene Therapy Clinical Development publishes data relevant to the regulatory review and commercial development of cell and gene therapy products. Pre-clinical papers focus on pharmacology/toxicity/bio-distribution experiments used in the review of proposed clinical trials and will contain sufficient information to allow referencing between products within the same technology platform when appropriate.

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The Official Journal of nine international societies:

DG-GT e.V.


Indexed/Abstracted in:

MEDLINE; PubMed; PubMed Central; Current Contents®/Life Sciences; Science Citation Index Expanded; Science Citation Index®; Biotechnology Citation Index®; Biological Abstracts; BIOSIS Previews; Journal Citation Reports/Science Edition; Derwent Drug File; EMBASE/Excerpta Medica; EMBiology; Scopus; Chemical Abstracts; ProQuest databases

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The views, opinions, findings, conclusions and recommendations set forth in any Journal article are solely those of the authors of those articles and do not necessarily reflect the views, policy or position of the Journal, its Publisher, its editorial staff or any affiliated Societies and should not be attributed to any of them.

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