Editors: Peter C. Johnson, MD and Antonios G. Mikos, PhD
Angiogenic control has proven to be one of the most difficult aspects of tissue engineering to master. This presents broad-based anatomic and physiologic challenges to the tissue engineer. Key controllers of angiogenesis have been formed to be mechanical forces, small molecules (drugs and growth factors), co-culture with non-vascular cells, biomaterials, and stem cells. This volume addresses vascular assembly techniques and the transplantation of microvascular networks.
Advances in Tissue Engineering, Volume 1: Angiogenesis presents leading-edge research and insight on:
- The mechanisms of angiogenesis, as studied in developmental biology models
- The application of systems biology to help us understand how choke points might be controlled by drugs or other approaches
- The physiological functioning of engineered capillaries, venules, and arterioles
- Creation of networks that have large enough arterial and venous components to enable direct anastomosis to host vessels
- Vascular assembly techniques and transplantation of microvascular networks