Editors: Peter C. Johnson, MD and Antonios G. Mikos, PhD
Table of Contents
Part 1-Strategic Importance of Angiogenesis in Tissue Engineering
Chapter 1-Strategic Directions in Tissue Engineering
Peter C. Johnson, Antonios G. Mikos, John P. Fisher, and John A. Jansen
Part 2-Review of Angiogenesis
Chapter 2-Vascularization—The Conduit to Viable Engineered Tissues
Tamar Kaully, Keren Kaufman-Francis, Ayelet Lesman, and Shulamit Levenberg
Part 3-Control Mechanisms for Vascular Growth
Mechanical Forces
Chapter 3-Interstitial Fluid Flow Intensity Modulates Endothelial Sprouting in Restricted Src-Activated Cell Clusters During Capillary Morphogenesis
Rodrigo Hernández Vera, Elsa Genové, Lery Alvarez, Salvador Borrós, Roger Kamm,
Douglas Lauffenburger, and Carlos E. Semino
Chapter 4-Effects of the Mechanical Properties of Collagen Gel on the In Vitro Formation of Microvessel Networks by Endothelial Cells
Nahoko Yamamura, Ryo Sudo, Mariko Ikeda, and Kazuo Tanishita
Chapter 5-Mechanical Strain Regulates Endothelial Cell Patterning In Vitro
Takuya Matsumoto, Yu Ching Yung, Claudia Fischbach, Hyun Joon Kong,
Ryusuke Nakaoka, and David J. Mooney
Drugs and Growth Factors
Chapter 6-Small Molecule Inducers of Angiogenesis for Tissue Engineering
Kristen A. Wieghaus, Scott M. Capitosti, Christopher R. Anderson, Richard J. Price,
Brett R. Blackman, Milton L. Brown, and Edward A. Botchwey
Chapter 7-Mechanistic Exploration of Phthalimide Neovascular Factor 1 Using Network Analysis Tools
Kristen A. Wieghaus, Erwin P. Gianchandani, Milton L. Brown, Jason A. Papin, and
Edward A. Botchwey
CHapter 8-Delivery of Basic Fibroblast Growth Factor from Gelatin Microsphere Scaffold for the Growth of Human Umbilical Vein Endothelial Cells
Xin Hao Zhu, Yasuhiko Tabata, Chi-Hwa Wang, and Yen Wah Tong
Chapter 9-Vascularization and Improved In Vivo Survival of VEGF-Secreting Cells Microencapsulated in HEMA-MMA
Jennifer J. Vallbacka, and Michael V. Sefton
Chapter 10-Platelet-Rich Plasma: Quantification of Growth Factor Levels and the Effect on Growth and Differentiation of Rat Bone Marrow Cells
Juliette Van Den Dolder, Rob Mooren, Annelies P.G. Vloon, Paul J.W. Stoelinga,
and John A. Jansen
Chapter 11-Vascular Endothelial Growth Factor-Releasing Scaffolds Enhance Vascularization and Engraftment of Hepatocytes Transplanted on Liver Lobes
Alon Kedem, Anat Perets, Iris Gamlieli-Bonshtein, Mona Dvir-Ginzberg,
Solly Mizrahi, and Smadar Cohen
Co-Culture With Non-Vascular Cells
Chapter 12-Human Aortic Smooth Muscle Cells Promote Arteriole Formation by Coengrafted Endothelial Cells
Benjamin R. Shepherd, Steven M. Jay, W. Mark Saltzman, George Tellides, and
Jordan S. Pober
Chapter 13-Microvessel-Like Structures from Outgrowth Endothelial Cells from Human Peripheral Blood in 2-Dimensional and 3-Dimensional Co-Cultures with Osteoblastic Lineage Cells
Sabine Fuchs, Alexander Hofmann, and C. James Kirkpatrick
Chapter 14-Endothelial Cells Assemble into a 3-Dimensional Prevascular Network in a Bone Tissue Engineering Construct
Jeroen Rouwkema, Jan De Boer, and Clemens A. Van Blitterswijk
Chapter 15-In Vitro 3D Model for Human Vascularized Adipose Tissue
Jennifer H. Kang, Jeffrey M. Gimble, and David L. Kaplan
Biomaterial Guidance
Chapter 16-Micropatterning of Poly(Ethylene Glycol) Diacrylate Hydrogels with Biomolecules to Regulate and Guide Endothelial Morphogenesis
James J. Moon, Mariah S. Hahn, Iris Kim, Barbara A. Nsiah, and Jennifer L. West
Chapter 17-Vascularized Adipose Tissue Grafts from Human Mesenchymal Stem Cells with Bioactive Cues and Microchannel Conduits
Michael S. Stosich, Barb Bastian, Nicholas W. Marion, Paul A. Clark,
and Gwendolen Reilly, Jeremy J. Mao
Chapter 18-Design of a Filamentous Polymeric Scaffold for In Vivo Guided Angiogenesis
Yossi Gafni, Yoram Zilberman, Zohar Ophir, Rinat Abramovitch, Michael Jaffe,
Zulma Gazit, Avraham Domb, and Dan Gazit
Chapter 19-A Biomaterial Composed of Collagen and Solubilized Elastin Enhances Angiogenesis and Elastic Fiber Formation Without Calcification
Willeke F. Daamen, Suzan T.M. Nillesen, Ronnie G. Wismans, Dieter P. Reinhardt,
Theo Hafmans, Jacques H. Veerkamp, and Toin H. van Kuppevelt
Chapter 20-Enhancing Efficacy of Stem Cell Transplantation to the Heart with a PEGylated Fibrin Biomatrix
Ge Zhang, Qingsong Hu, Elizabeth A. Braunlin, Laura J. Suggs, and Jianyi Zhang
Stem Cells
Chapter 21-In Vitro Angiogenesis Properties of Endothelial Progenitor Cells: A Promising Tool for Vascularization of Ex Vivo Engineered Tissues
Günter Finkenzeller, Nestor Torio-Padron, Arash Momeni, Alexander T. Mehlhorn,
and G. Björn Stark
Chapter 22-Comparative Analysis of Methods for Assessment of Circulating Endothelial Progenitor Cells
Jacob George, Haim Shmilovich, Varda Deutsch, Hylton Miller, Gad Keren, and Arie Roth
Chapter 23-Mesenchymal Stem Cells Enhance Angiogenesis in Mechanically Viable Prevascularized Tissues via Early Matrix Metalloproteinase Upregulation
Cyrus M. Ghajar, Katherine S. Blevins, Christopher C.W. Hughes, Steven C. George,
and Andrew J. Putnam
Chapter 24-Influence of Adult Mesenchymal Stem Cells on In Vitro Vascular Formation
J. Michael Sorrell, Marilyn A. Baber, and Arnold I. Caplan
Chapter 25-Use of Embryonic Stem Cell-Derived Endothelial Cells as a Cell Source to Generate Vessel Structures In Vitro
Kara E. McCloskey, Meghan E. Gilroy, and Robert M. Nerem
Part 4-Vascular Assembly Techniques
Chapter 26-Prevascularization of a Fibrin-Based Tissue Construct Accelerates the Formation of Functional Anastomosis with Host Vasculature
Xiaofang Chen, Anna S. Aledia, Cyrus M. Ghajar, Craig K. Griffith,
Andrew J. Putnam, Christopher C.W. Hughes, and Steven C. George
Chapter 27-Characterizing Environmental Factors that Impact the Viability of Tissue-Engineered Constructs Fabricated by a Direct-Write Bioassembly Tool
Cynthia M. Smith, Joseph J. Christian, William L. Warren, and Stuart K. Williams
Chapter 28-Novel Intra-Tissue Perfusion System for Culturing Thick Liver Tissue
Yuet Mei Khong, Jing Zhang, Sibo Zhou, Christine Cheung, Kai Doberstein,
Victor Samper, and Hanry Yu
Part 5-Transplantation of Microvascular Networks
Chapter 29-Microvascular Transplantation After Acute Myocardial Infarction
Benjamin R. Shepherd, James B. Hoying, and Stuart K. Williams