Editor: Chandan K. Sen, PhD
Table of Contents
PREFACE
Editor-in-Chief: Chandan K. Sen
Chapter 1
Strengthening the Interdisciplinary Continuum of Wound Care
Chandan K. Sen
SECTION 1: MILITARY WOUND CARE
Section Editors: Alexander Stojadonivic and Eric Elster
Chapter 2
War and Medicine: A Brief History of the Military’s Contribution to Wound Care Through World War I
George Broughton II and David Burris
Chapter 3
History of Bacteriology of War Wounds
Forest R. Sheppard and Martin C. Robson
Chapter 4
Trauma System Approach to Complex Wounded
Mathew J. Bradley and James R. Dunne
Chapter 5
In-Theatre Wound Care
Sean P. Montgomery and Lorne Blackbourne
Chapter 6
Update on Bioburden Control and Treatment of War Wound Infections
Kyle Petersen, Duane Hospenthal, and Glenn Wortmann
Chapter 7
Damage Control in the War Wounded
Scott R. Steele and George E. Peoples
Chapter 8
Management of the Open Abdominal Wound
Amy Vertrees and Craig Shriver
Chapter 9
Heterotopic Ossification in High-Energy War Wounds
Jonathan Agner Forsberg and Benjamin Kyle Potter
Chapter 10
The Mangled Extremity
Romney C. Andersen, Scott B. Shawen, John J. Keeling, and Robert V. O’Toole
Chapter 11
Advances in Amputee Care
Kevin F. Fitzpatrick, Paul F. Pasquina, and Charles Scoville
Chapter 12
Plastic Surgery Challenges in War Wounded
Anand R. Kumar, Raymond Harshbarger, and Barry Martin
Chapter 13
The Use of Three-Dimensional Models in the Treatment of Craniomaxillofacial Injuries
Phillip Littlefield, Christopher Cote, and George Coppit
SECTION 2: ACUTE WOUNDS
Section Editors: Adrian Barbul and David Leaper
Chapter 14
Surgical Site Infections
David Leaper and Adrian Barbul
Chapter 15
Smoking and Postsurgical Wound Healing—An Update on Mechanisms and Biological Factors
Lars Tue Sørensen and Finn Gottrup
Chapter 16
Pilonidal Sinus: Healing by Primary Closure Versus Open Healing Surgery
Luc Téot and Pascal Granier
Chapter 17
Honey as a Topical Treatment for Wounds
Zena Moore
Chapter 18
Prolene Hernia System, Lichtenstein Mesh, and Plug and Patch for Primary Inguinal Hernia: A 3-Year Randomized Controlled Trial
Vijay A. Singh, Sandra L. Kavalukas, and Adrian Barbul
Chapter 19
Use of Human Acellular Dermal Matrix for Hernia Repair: Friend or Foe?
Vijay Singh, Sandra Kavalukas, and Adrian Barbul
SECTION 3: DRESSINGS
Section Editors: Dorothy Weir and Hariett Loehne
Chapter 20
Introduction to Dressings
Patricia Mann Mertz
Chapter 21
Hydrocolloids: Healing by Occlusion
Cathy Thomas Hess
Chapter 22
Skin Protectants in the Treatment of Irritant Dermatitis Associated with Exposure to the Body’s Effluents
Mikel Gray
Chapter 23
Gauze, Impregnated Gauzes, and Contact Layers
Renee Cordrey
Chapter 24
Transparent Film Dressings
Susie Seaman
Chapter 25
Hydrogel Dressings
Karen Lou Kennedy-Evans and James B. Lutz
Chapter 26
Foam Dressings
Melodie Blakely
Chapter 27
Absorptive Dressings: Alginates and Hydrofibers
Karen A. Gibbs
Chapter 28
Antibacterial Dressings
Rose L. Hamm
Chapter 29
Occlusive Versus Gauze Dressings for Local Wound Care in Surgical Patients
Zena Elizabeth Helen Moore
SECTION 4: CHRONIC WOUNDS
Section Editors: Robert Kirsner and Robert Galiano
Chapter 30
Cellular and Molecular Mechanism of Chronic Wounds
Karen Zimmerman, Olivera Stojadinovic, Marjana Tomic-Canic, and Harold Brem
Chapter 31
Cellular and Molecular Mechanism of Chronic Wounds
Elizabeth Lebrun
Chapter 32
Healing Competence of the Keratinocytes and the Chronic Wound Edge
Olivera Stojadinovic, Marilyn Zabielinski, and Marjana Tomic-Canic
Chapter 33
Age and Impaired Healing Potential
Jason Maggi, Madhu Ragupathi, Marjana Tomic-Canic, and Harold Brem
Chapter 34
The Role of Stress in Wound Healing
Loretta Vileikyte and Matthew Hardman
Chapter 35
Novel Mechanisms on the Pathophysiology of Venous Ulcers
Barbara Pieper, Robert S. Kirsner, and Thomas N. Templin
Chapter 36
Clinical Trials: The Use of Surrogate Endpoints
David J. Margolis
SECTION 5: INFLAMMATION
Section Editors: Luisa DiPietro and Sashwati Roy
Chapter 37
Neuroinflammatory Modulation of Cutaneous Responses to Injury
Anne N. Hocking, Lara A. Muffley, and Nicole S. Gibran
Chapter 38
Cytokines and Growth Factors in the Regulation of Wound Inflammation
Tim D. Eubank and Clay B. Marsh
Chapter 39
A Family of Small Cytokines Called Chemokines Is Important in Regulation of Wound Repair
Manuela Martins-Green
Chapter 40
Amplifying Healing: The Role of Antimicrobial Peptides in Wound Repair
Katherine A. Radek and Richard Louis Gallo
Chapter 41
Lipid Mediators: Important Regulators of Cutaneous Wound Inflammation
Traci A. Wilgus
Chapter 42
Neutrophils and Mast Cells in Wound Healing
Luisa Ann DiPietro
Chapter 43
The Role of Mesenchymal Stem Cells and Fibrocytes in Wound Healing and Hypertrophic Scar Formation: Recent Advances
Jie Ding and Edward E. Tredget
Chapter 44
Linking the Advanced Glycation Endproducts/Receptor for Advanced Glycation Endproducts Pathway in Diabetics with Inflammation and Topical Antiinflammatory Treatments of Chronic Wounds
Gregory Schultz, Jorge Berlanga Acosta, Linda Cowan, and Joyce Stechmiller
Chapter 45
Resolution of Inflammation in Wound Healing: Significance of Dead Cell Clearance
Sashwati Roy
Chapter 46
Chronic Wounds and Inflammation
Sebastian Willenborg, Johanna Knipper, Rajeev Ranjan, Thomas Krieg, and Sabine A. Eming
Chapter 47
The Role of Fibrocytes in Wound Healing
Adriana Blakaj and Richard Bucala
Chapter 48
Postoperative Peritoneal Adhesion Formation: An Update
Richard Peter ten Broek and Harry van Goor
SECTION 6: BIOFILM
Section Editors: Philip S. Stewart and Gregory Schultz
Chapter 49
New Frontiers of Molecular Microbiology in Wound Healing
Swetha Kandula, Jonathan Mark Zenilman, Johan Humberto Melendez, and Gerald Sylvan Lazarus
Chapter 50
Ecology of Biofilms in Chronic Wounds
Thomas Bjarnsholt and Michael Givskov
Chapter 51
In Vitro Models for the Growth and Analysis of Chronic Wound Biofilms
Garth A. James, Alessandra Marçal Agostinho, and Elinor de Lancey Pulcini
Chapter 52
Effects of Antimicrobial Agents on an In Vitro Biofilm Model of Skin Wounds
Priscilla L. Phillips, Qingping Yang, Edith Sampson, and Gregory Schultz
Chapter 53
Animal Models of Biofilm-Infected Wound Healing
Anandev N. Gurjala, Clark F. Schierle, Robert D. Galiano, Kai P. Leung, and Thomas A. Mustoe
Chapter 54
Biofilm-Based Wound Care
Randall D. Wolcott, Scot Dowd, John Kennedy, and Curtis E. Jones
SECTION 7: OXYGEN AND ANGIOGENESIS
Section Editors: Omaida Velazquez and Gayle M. Gordillo
Chapter 55
The Impact of Hyperbaric Oxygen on Cutaneous Wound Repair
Stephen R. Thom
Chapter 56
Angiogenesis in Wound Healing: The Role of Oxygen
Zhao-Jun Liu and Omaida C. Velazquez
Chapter 57
Spinal Cord Injury and Repair: Role of Blood Vessel Loss and Endogenous Angiogenesis
Martin Oudega
Chapter 58
Design of a Novel Protease-Resistant Vascular Endothelial Growth Factor-A Protein for Angiogenic Therapy
Stephanie Traub, Tina Lucas, Daniel Hoffmann, Thomas Krieg, and Sabine A. Eming
Chapter 59
Angiogenesis in Chronic Wounds
Tengjiao Cui, Robert Kirsner, and Jie Li
Chapter 60
Tiny New Genes Called MicroRNAs Regulate Blood Vessel Formation
Chandan K. Sen
SECTION 8: GENE- AND PROTEIN-BASED THERAPIES
Section Editors: Jeffrey M Davidson and Sabine Eming
Chapter 61
Gene Transfer Techniques for Therapeutic Angiogenesis
Sundeep G. Keswani and Timothy M. Crombleholme
Chapter 62
Smart Growth Factor Gene Delivery for Impaired Wound Healing
María José Escámez, Marta Carretero, Marta García, Lucía Martínez-Santamaría, Fernando Larcher, and Marcela Del Río
Chapter 63
Platelet-Derived Growth Factor Delivery via Nanofibrous Scaffolds for Soft-Tissue Repair
Qiming Jin, Peter X. Ma, and William V. Giannobile
Chapter 64
Gene Delivery to Wounds Using Allogenic Keratinocytes
Taro Koyama, Pejman Aflaki, Jan Jeroen Vranckx, Feng Yao, and Elof Eriksson
Chapter 65
Plasmid-Based Gene Transfer of Homeobox Genes and Improved Wound Healing
Kimberly A. Mace and Nancy Boudreau
Chapter 66
Clinical Biomaterials for Scar-Free Healing and Localized Delivery of Cells and Growth Factors
Glenn D. Prestwich
Chapter 67
Matrix-Enabled Gene Delivery for Tissue Repair
Lois A. Chandler, Robert Engler, and Barbara K. Sosnowski
SECTION 9: TISSUE ENGINEERING
Section Editors: Jonathan Mansbridge and Hans-O Rennekampf
Chapter 68
Tissue-Engineered Skin Substitutes
Jonathan Noel Mansbridge and Oliver Rennekampf
Chapter 69
Developments in Cell-Based Therapy for Wounds
Vincent Ronfard and Thomas Williams
Chapter 70
Fibroblast Subsets for Skin Substitute Engineering
Hans-Oliver Rennekampff, Weiguo Xu, and H. Peter Rodemann
Chapter 71
Human Skin–Equivalent Platforms for the Preclinical Development and Testing of New Wound Healing Agents
Christophe Egles and Jonathan A. Garlick
Chapter 72
Future Perspectives of Tissue-Engineered Skin: Xenobiotic-Free Culture Systems
Neeltje A. Coolen, Magda M.W. Ulrich, and Esther Middelkoop
Chapter 73
The Use of a Collagen–Elastin Matrix as Dermal Regeneration Template for the Treatment of Full-Thickness Skin Defects
Werner Haslik, David B. Lumenta, Lars Peter Kamolz, and Manfred Frey
Chapter 74
How to Achieve Early Vascularization of Tissue-Engineered Skin Substitutes
François Berthod, Lucie Germain, Roxane Pouliot, and François A. Auger
Chapter 75
Self-Assembled Scaffold-Free Three-Dimensional Micro-Tissues for Tissue Repair
Jacquelyn Youssef and Jeffrey Morgan
Chapter 76
An Inductive Approach to Wound Repair and Regeneration Using a Tissue-Engineered Product
Damien Bates and Stephen Farrell
SECTION 10: STEM AND PROGENITOR CELLS
Section Editors: Timothy Crombleholme and Kenneth Liechty
Chapter 77
Mesenchymal Stem Cells and Wound Repair
Charles Bellows and Donald G. Phinney
Chapter 78
Mesenchymal Stem Cells in Ischemic Wound Healing
Susan W. Volk
Chapter 79
Mesenchymal Stem Cells in Diabetic Wound Healing
Dustin M. Bermudez and Kenneth W. Liechty
Chapter 80
The Systems Biology of Diabetic Wound Healing: Insights from Transcriptomic and Functional Genomics Analyses
Arturo R. Maldonado, Bruce J. Aronow, and Timothy M. Crombleholme
Chapter 81
Bone Marrow Adult Stem and Progenitor Cells in the Treatment of Chronic Wounds
John Kowalczyk and Evangelos Badiavas
Chapter 82
A Review of the Therapeutic Potential of Adipose-Derived Stem Cells
Liam C. Macleod, Aaron W. James, Antoine L. Carre, Michael T. Longaker, and Hermann P. Lorenz
Chapter 83
Endothelial Progenitor Cell’s Contribution to Wound Healing and Skin Graft Neovascularization
Michael G. Galvez, Edward I. Chang, and Geoffrey C. Gurtner
Chapter 84
The Role of Bone Marrow–Derived Endothelial Progenitor Cells in Neovascularization of Engineered Skin Substitute
Lee M. Morris, Timothy M. Crombleholm, and Edward J. Doolin
Chapter 85
In Vitro Assays for Wound Healing Properties of Stem Cells
Edward Doolin
Chapter 86
Progenitor Cells for the Treatment of Acute Myocardial Infarction
Robert Gorman
Chapter 87
Stem Cells in Hepatic Regeneration Following Injury
Katherine Bianco
SECTION 11: DEVICES
Section Editors: Paul Liu and Lisa Gould
Chapter 88
What Is New in Debridement?
Stephen C. Davis and Aron G. Nusbaum
Chapter 89
Debridement in Surgical Wounds
Luc Téot
Chapter 90
Recent Advances in the Use of Ultrasound in Wound Care
Vickie R. Driver and Matteo Fabbi
Chapter 91
Topical Negative Pressure Therapy for Acute and Chronic Wounds
Zena Elizabeth Helen Moore
Chapter 92
Tangential Hydrosurgery—A New Tool for Wound Debridement
Mark J. Ferretti and Paul Y. Liu
Chapter 93
Electrical Activation of Wound-Healing Pathways
Min Zhao, Josef Penninger, and Roslyn Rivkah Isseroff
Chapter 94
The Value of Wound Care Devices
Kris Kieswetter, Gregory D. Kunst, and Maggie McMahon
SECTION 12: PUBLIC–PRIVATE PARTNERSHIP
Section Editors: Kris Kieswetter, Lynn Lambert, and Katy Rowland
Chapter 95
Wound Management Services and Academic Partnerships
Katy Rowland and Peter Metcalfe
Chapter 96
Time is Tissue—How Early and Accurate Assessment of Lower Extremity Peripheral Arterial Disease Leads to Favorable Outcomes
Paul L. Vaughn
Chapter 97
Developing a Gene-Activated Matrix Product for Chronic Wounds: A Biotech’s Perspective
Barbara K. Sosnowski, Robert Engler, and Lois A. Chandler
Chapter 98
Ultrasound Therapy for Wound Healing, Evidence-Informed Treatment Decision Making
Malgorzata Plummer, Patricio Meneses, and William J. Ennis
Chapter 99
Microvascular Diagnostics in Wound Care
Jenny Ellen Freeman and Anita Karcz