Editor: Chandan K. Sen
Table of Contents
Preface
Delivering Solutions in Wound Care Through Interdisciplinary Science and Partnerships
Editor-in-Chief: Chandan K. Sen
SECTION 1: STEM AND PROGENITOR CELL THERAPY
Section Editors: Geoffrey Gurther and Robert Galiano
Chapter 1
Skin Stem Cells and Wound Healing
Qiong Zeng, Atulya Prasad, Steve A. McClain, and Richard Clark
Chapter 2
Adipose-Derived Stem Cells: Origin and Lineage
Kacey G. Marra, Arta Kelmendi-Doko, and Joseph Rubin
Chapter 3
Induced Pluripotent Stem Cells
Sae Hee Ko, Allison Nauta, Geoffrey Gurtner, and Michael T. Longaker
Chapter 4
Nonviral Reprogramming: Toward a Safer Induced Pluripotent Stem Cell
Arwen L. Hunter and John P. Cooke
Chapter 5
Remembering Your Roots: Importance of Cellular Memory in Wound Healing and Limb Regeneration
Ludan Zhao and Jill A. Helms
SECTION 2: SKIN REGENERATION
Section Editors: Lillian Nanney and Susan Opalenik
Chapter 6
Adipose Derived Stem Cells as a Key Strategy of Cell-based Therapy to Promote Wound Healing
Radia Tamarat, Marc Benderitter, and Patrick Gournelon
Chapter 7
Epithelial-Mesenchymal Cross-Talk in Dermal Wound Healing
Yunyuan Li, Abdi Ghaffari, and Aziz Ghahary
Chapter 8
Advances in Scaffoldings and Biomaterials
Britlyn D. Orgill and Dennis P. Orgill
Chapter 9
Adult Skin Wounds Can Be Induced to Regenerate Through Modulation of Cells and Extracellular Matrix Molecules
Dariush Honardoust and Edward Tredget
Chapter 10
Homeobox Genes and Wound Healing: Evidence Linking Development and Skin Regeneration
Mauricio Kuri, Kyle Belek, and Nancy J. Boudreau
Chapter 11
In Vitro Reconstructed Human Skin Equivalents for Autologous Transplantation in Burns, Chronic Ulcers, and Pigment Defects
Liliana Guerra, Desanka Raskovic, Chiara De Luca, and Liudmila G. Korkina
SECTION 3: INFLAMMATION
Section Editors: Samuel J. Leibovich and Kurt Lu
Chapter 12
Macrophages and Wound Healing
Luisa Ann DiPietro and Timothy J. Koh
Chapter 13
Resolution of Wound Inflammation: Significance of Apoptotic Cell Phagocytosis
Sashwati Roy
Chapter 14
Inflammation Impairs Wound Healing in Diabetic Mice
Dana Graves and Mohan R. Dasu
Chapter 15
Macrophage Heterogeneity and Wound Healing
Grace Enfield and Samuel J. Leibovich
Chapter 16
Ecto-5’-Nucleotidase (CD73)-Mediated Extracellular Adenosine Production Plays a Critical Role in Wound Healing and Fibrosis
Edwin S.L. Chan and Bruce N. Cronstein
Chapter 17
Genetic Analyses of Inflammation and Wound Healing
Tanya J. Shaw and Brian M. Stramer
Chapter 18
Roles of MicroRNA in Wound Healing
Maha Abdellatif
SECTION 4: OXYGEN
Section Editors: Harriet Hopf and Dick Clarke
Chapter 19
Hypoxia-Inducible MicroRNAs in Chronic Ischemic Wounds
Jaideep Banerjee and Chandan K. Sen
Chapter 20
Oxygen-Derived Hydrogen Peroxide as a Key Signal for Wound Healing
Chandan K. Sen
Chapter 21
Enhancing Wound Oxygen Levels: Effectiveness of Hydration and Transdermal Oxygen Therapies
JoAnne D. Whitney
Chapter 22
Oxygen Toxicity
Michael Bennett
SECTION 5: GENE and PROTEIN BASED THERAPIES
Section Editors: Jeffrey Davidson and Scott Guelcher
Chapter 23
Sustained Release and Dual Delivery Strategies for Platelet-derived Growth Factor
Scott A. Guelcher
Chapter 24
Human Beta-Defensins Improve Wound Healing Through a Mechanism Affecting Multi-aspects of the Healing Process
Huiqin Sun, Mingke Wang, Lei Hao, Junping Wang, Yongping Su, and Zhongmin Zou
Chapter 25
A New Future for Growth Factor Complexes as Wound Therapies?
David I. Leavesley and Zee Upton
Chapter 26
Hypoxia-Inducible Factor 1a Gene Therapy Promotes Wound Vascularization in Diabetic Mice
Gregg L. Semenza
Chapter 27
The Diabetic Wound: A New Experimental Wound Healing Model in Large Animals
Florian Hackl, Elizabeth Klwanuka, Daniel Nowinski, and Elof Eriksson
Chapter 28
Sonic Hedgehog Accelerates Wound Healing Via Enhancing Cutaneous Nitric Oxide Function in Diabetes
Jie-Mei Wang, Jian-Dong Luo, and Alex F. Chen
SECTION 6: ANTI-SCAR STRATEGIES
Section Editors: Tai-Lan Tuan and Praveen Arany
Chapter 29
Keloids: Current Progress in Basic Research and Management
George P. Yang
Chapter 30
Management of Scars with Lasers
Jennifer L. MacGregor and Tina S. Alster
Chapter 31
Recent Advances in Pathophysiology and Management of Burn Scar
Keijiro Hori and Edward E. Tredget
Chapter 32
Targeted Approaches to Scar Management Based on Our Current Understanding of Triggers, Modulators, and Effectors of Aberrant Healing
Praveen R. Arany and Tai-Lan Tuan
Chapter 33
Targeting Fibrinolysis as a Therapeutic Strategy to Prevent Abdominal Adhesion Formation
Sarah Herrick and Malcolm Wilson
Chapter 34
New Insights into the Basis of the Activated Fibroblast Phenotype in Scleroderma
Andrew Leask
SECTION 7: CHRONIC WOUNDS
Section Editors: Robert Kirsner and Stephanie Wu
Chapter 35
The Use of Topical Antimicrobials and Antibiotics in Wound Care
Warren S. Joseph
Chapter 36
Update on Venous Ulcerations
Allen Holloway
Chapter 37
Clinical Perspective on Interpreting Wound Care Efficacy Studies and Interpretation
Laura L. Bolton
Chapter 38
Healing of Ischemic Wounds
William Marston
Chapter 39
Update on Standards of Wound Care
Laura L. Bolton
Chapter 40
Heal Ohio Experience: A Collaborative Model
Robert Anthony, Judith Fulton and Eliot Marstow
Chapter 41
Current Opportunities and Challenges in the Business of Wound Care Management
James E. Patrick
SECTION 8: CRITICAL LIMB ISCHEMIA
Section Editors: Vickie R. Driver and William Li
Chapter 42
Noninvasive Diagnostics for Critical Limb Ischemia
Silvia Garcia-Lavin, Matteo Fabbi, Robert Eberhardt, and Vickie R. Driver
Chapter 43
Gene- and Molecular-based Therapy for Critical Limb Ischemia
Arabindra B. Katwal and Brian H. Annex
Chapter 44
The Role of Heparin in Wound Healing
Bonnie Lin, Matteo Fabbi, and Vickie R. Driver
Chapter 45
Outcomes and Advances in Bypass Surgery
Jeffrey Kalish and Alik Farber
Chapter 46
Outcomes and Advances in Endovascular Surgery
Palma Shaw and Tony Nguyen
Chapter 47
The Impact of Chronic Lower Limb Wounds on a Person’s Quality of Life
Patricia E. Price and Elizabeth J. Mudge
SECTION 9: ACUTE WOUNDS
Section Editors: Adrian Barbul and David Leaper
Chapter 48
Omega-3 Fatty Acids Modulate Wound Healing
Valy Boulom and Adrian Barbal
Chapter 49
Acute Ruptures of the Achilles Tendon
Rebecca Tate and Mike R. Reed
Chapter 50
New Advances in Adhesion Mechanism and Prevention
Sandra Kavalukas and Adrian Barbul
Chapter 51
Perforator Flaps and Wound Flap Update
Geoffrey G. Hallock
SECTION 10: BURNS
Section Editors: Nicole Gibran and Anne Hocking
Chapter 52
Review of Recent Experimental and Clinical Studies of Topical Agents for Burn Wounds
Tam Pham
Chapter 53
Tissue Engineering Applications for Burn Wounds
David A. Brown
Chapter 54
New Models of Burn Wound Injury and Repair
Corrie L. Gallant-Behm
Chapter 55
Novel Diagnostic Tools for Burn Wounds
James C. Jeng
Chapter 56
The Role of Osteopontin, Angiotensin-II, Peroxisome Proliferator–Activated Receptor-g, Keratinocyte-Derived Factors, and Mechanical Tension in Skin Wound Healing and Fibrosis: Recent Advances
Matthew Varkey and Edward E. Tredget
SECTION 11: REIMBURSEMENT UPDATES
Section Editor: Kathleen Schaum
Chapter 57
Coding for Wound Care Products, Procedures, and Services: An Overview
Donna J. Cartwright
Chapter 58
Medicare Coverage Decisions for Wound Care Products, Procedures, and Services: An Overview
Kathleen D. Schaum
Chapter 59
Payment for Wound Care Products, Procedures, and Services: An Overview
Peggy Dotson
Index