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Published Online: 5 July 2004

In Vitro Replication of SIVcpz Is Suppressed by β-Chemokines and CD8+ T Cells But Not by Natural Killer Cells of Infected Chimpanzees

Publication: AIDS Research and Human Retroviruses
Volume 18, Issue Number 5

Abstract

Unlike humans, chimpanzees are relatively resistant to AIDS after infection with HIV-1 or simian immunodeficiency virus of chimpanzee (SIVcpz). We hypothesized that resistance to disease progression is associated with efficient suppression of virus replication possibly by β-chemokines secreted by CD8+ lymphocytes and especially natural killer (NK) cells. In vitro suppression of virus replication can be easily studied in SIVcpz-infected chimpanzees because they produce high infectious virus titers in their peripheral blood. A study was undertaken to assess the sensitivity of SIVcpz to β-chemokines in vitro and to investigate the role of endogenous β-chemokines in relation to the in vitro capacity of CD8+ lymphocytes and NK cells of chimpanzees to suppress SIVcpz replication. Our results show that SIVcpz uses CCR5 as a coreceptor to gain cell entry and is sensitive to recombinant β-chemokines in vitro. Here we report that despite their potent capacity to produce RANTES, NK cells of infected chimpanzees do not suppress SIVcpz replication in vitro, in contrast to CD8+ lymphocytes. We also show that endogenous β-chemokines are not the predominant factors mediating in vitro suppression.

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Published In

cover image AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses
Volume 18Issue Number 5March 2002
Pages: 373 - 382
PubMed: 11897039

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Published online: 5 July 2004
Published in print: March 2002

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Pascale Ondoa
Departments of Microbiology and Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium
Johan Vingerhoets
VIRCO Group of Companies, B-2800 Mechelen, Belgium
Chris Vereecken
Departments of Microbiology and Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium
Guido van der Groen
Departments of Microbiology and Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium
Jonathan L. Heeney
Department of Virology, Biomedical Primate Research Center, Rijswijk 2280 GH, The Netherlands
Luc Kestens
Departments of Microbiology and Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium

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