Research Article
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Published Online: 5 July 2004

Effect of Complement Consumption by Cobra Venom Factor on the Course of Primary Infection with Simian Immunodeficiency Virus in Rhesus Monkeys

Publication: AIDS Research and Human Retroviruses
Volume 15, Issue Number 2

Abstract

Cobra venom factor (CVF)-induced consumption of complement proteins was used to investigate the role of complement in vivo in the immunopathogenesis of simian immunodeficiency virus of macaques (SIVmac) infection in rhesus monkeys. Repeated administration of CVF was shown to deplete complement to < 5% of baseline hemolytic activity of serum complement for 10 days in a normal monkey. Three groups of SIVmac-infected animals were then evaluated: monkeys treated with CVF resulting in complement depletion from days - 1 to 10 postinfection, monkeys treated with CVF resulting in complement depletion from days 10 to 21 postinfection, and control monkeys that received no CVF. CD8+ SIVmac-specific cytotoxic T lymphocyte (CTL) generation and CD4+ T lymphocyte depletion during primary infection were not affected by CVF treatment. Viral load, assessed by measurements of plasma p27gag antigen and viral RNA, was transiently higher during the first 4 weeks following infection in the CVF-treated monkeys and the subsequent clinical course in these treated animals was accelerated. These results suggest that complement proteins may participate in immune defense mechanisms that decrease virus replication following the initial burst of intense viremia during primary SIVmac infection. However, we cannot rule out that the observed increased virus replication was induced by immune activation resulting from the administration of a foreign antigen to these monkeys.

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Published In

cover image AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses
Volume 15Issue Number 2January 1999
Pages: 195 - 202
PubMed: 10029251

History

Published online: 5 July 2004
Published in print: January 1999

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