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Published Online: 8 July 2004

A Model Of Acute Subdural Hematoma In The Mouse

Publication: Journal of Neurotrauma
Volume 18, Issue Number 11

Abstract

The availability of genetically modified mice has allowed the study of genetic influences on acute brain injury. An animal model of acute subdural hematoma (ASDH) has been previously described in the rat but not the mouse. We describe a method for producing ASDH in the mouse. Subdural injections of 50 and 30 μL of nonheparinized autologous blood were associated with excessive mortality. Injections of 10 and 20 μL were associated with mean percentage volumes of damage of 1.804% and 4.019%, respectively. Sham subdural injections of saline were associated with minimal hemisphere damage (0.152%). This mouse model provides a means of investigating the effects of genotype on the brain's response to ASDH.

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Published In

cover image Journal of Neurotrauma
Journal of Neurotrauma
Volume 18Issue Number 11November 2001
Pages: 1241 - 1246
PubMed: 11721742

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Published online: 8 July 2004
Published in print: November 2001

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    Mitsuyoshi Sasaki
    Department of Neurosurgery, Nippon Medical School 2nd Hospital, Kawasaki, Japan
    Laurence Dunn
    Department of Neurosurgery, Institute of Neurological Sciences, Glasgow, United Kingdom

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