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Published Online: 9 July 2004

Accuracy of Three-Dimensional Ultrasound for Thyroid Volume Measurement in Children and Adolescents

Publication: Thyroid
Volume 14, Issue Number 2


The aim of this study was to estimate accuracy, intraobserver variability, and repeatability of thyroid volume measurement by ultrasound using conventional two-dimensional ellipsoid model (2D US) and manual planimetry of three-dimensional images (3D US). The sonographic images of 47 children with thyroid nodular pathology who were referred for thyroid surgery in Belarus were evaluated prospectively. Two-dimensional images were acquired using the ultrasound scanner with 7.5-MHz linear probe. Three-dimensional data sets were created using three-dimensional system, FreeScan. For each patient thyroid volume was measured three times using both two- and three-dimensional methods. Results of volume estimation were then compared to the volume of thyroid gland determined after surgery. Standardized difference between thyroid volume estimated by ultrasound and surgery (mean ± standard deviation (SD), %) for 3D and 2D US methods was 1.8 ± 5.2% and 3.2 ± 15.3%, respectively. The 3D US has lower intraobserver variability (3.4%) and higher repeatability (96.5%) than 2D US with 14.4% variability and 84.8% repeatability (p < 0.001). In conclusion, three-dimensional sonography allows accurate measurement of thyroid volume with low intraobserver variability and high repeatability.

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Published In

cover image Thyroid®
Volume 14Issue Number 2February 2004
Pages: 113 - 120
PubMed: 15068625


Published online: 9 July 2004
Published in print: February 2004


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Andrej Lyshchik
Laboratory of Thyroidology, Clinical Research Institute for Radiation Medicine and Endocrinology, Minsk, Belarus and Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Kyoto, Japan
Valentina Drozd
Laboratory of Thyroidology, Clinical Research Institute for Radiation Medicine and Endocrinology, Minsk, Belarus
Christoph Reiners
Clinic and Policlinic for Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany

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