Research Article
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Published Online: 9 July 2004

Microsyringe-Based Deposition of Two-Dimensional and Three-Dimensional Polymer Scaffolds with a Well-Defined Geometry for Application to Tissue Engineering

Publication: Tissue Engineering
Volume 8, Issue Number 6

Abstract

A technique for controlled deposition of biomaterials and cells in specific and complex architectures is described. It employs a highly accurate three-dimensional micropositioning system with a pressure-controlled syringe to deposit biopolymer structures with a lateral resolution of 5 μm. The pressure-activated microsyringe is equipped with a fine-bore exit needle and a wide variety of two- and three-dimensional patterns on which cells to be deposited can adhere. The system has been characterized in terms of deposition parameters such as applied pressure, motor speed, line width and height, and polymer viscosity, and a fluid dynamic model simulating the deposition process has been developed, allowing an accurate prediction of the topological characteristics of the polymer structures.

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Published In

cover image Tissue Engineering
Tissue Engineering
Volume 8Issue Number 6December 2002
Pages: 1089 - 1098
PubMed: 12542954

History

Published online: 9 July 2004
Published in print: December 2002

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G. Vozzi
Interdepartmental Research Center E. Piaggio, University of Pisa, and Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Pisa, Italy
A. Previti
Interdepartmental Research Center E. Piaggio, University of Pisa, and Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Pisa, Italy
D. De Rossi
Interdepartmental Research Center E. Piaggio, University of Pisa, and Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Pisa, Italy
A. Ahluwalia
Interdepartmental Research Center E. Piaggio, University of Pisa, and Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Pisa, Italy

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