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Published Online: 5 July 2004

Imaging In Vivo Brain-Hormone Interaction in the Control of Eating and Obesity

Publication: Diabetes Technology & Therapeutics
Volume 3, Issue Number 4

Abstract

The field of neuroimaging has made great progress in the mapping of human brain function. In this article, we present a functional magnetic resonance imaging (fMRI) study on the hypothalamic regulation of satiety and its relationship with obesity. The fMRI techniques have been proven invaluable for analyzing changes in brain activity that are associated with most sensorimotor and cognitive functions. However, few studies have been successful in the delineation of the interaction between the central nervous system and the endocrine system, due to the lack of suitable mapping methods which can pinpoint the onset of changes in neuronal activity (e.g., those following eating or drug intake). We have recently introduced a new fMRI method known as temporal clustering analysis (TCA) for dynamically tracking the time course of brain activation. Along with simultaneous blood sampling for the circulating hormone levels, the fMRI techniques with TCA may provide an integrated view of the nervous and endocrine systems in vivo, and thus greatly enhance our understanding of the complex interplay between neural events and hormonal signals.

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Published In

cover image Diabetes Technology & Therapeutics
Diabetes Technology & Therapeutics
Volume 3Issue Number 4December 2001
Pages: 617 - 622
PubMed: 11911174

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Published online: 5 July 2004
Published in print: December 2001

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G. Andrew James
Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida.
Wei Guo
Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida.
Yijun Liu
Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida.

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