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Published Online: 18 May 2010

Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial

Publication: The Journal of Alternative and Complementary Medicine
Volume 16, Issue Number 5

Abstract

Objective: The objective of this study was to examine the effect of Cs-4® (Cordyceps sinensis) on exercise performance in healthy elderly subjects.
Design: Twenty (20) healthy elderly (age 50–75 years) subjects were enrolled in this double-blind, placebo-controlled, prospective trial. The subjects were taking either Cs-4 333 mg or placebo capsules 3 times a day for 12 weeks.
Measurement: Subjects received baseline screening including physical examination and laboratory tests. Maximal incremental exercise testing was performed on a stationary cycle ergometer using breath-by-breath analysis at baseline and at the completion of the study.
Results: After receiving Cs-4 for 12 weeks, the metabolic threshold (above which lactate accumulates) increased by 10.5% from 0.83 ± 0.06 to 0.93 ± 0.08 L/min (p < 0.02) and the ventilatory threshold (above which unbuffered H+ stimulates ventilation) increased by 8.5% from 1.25 ± 0.11 to 1.36 ± 0.15 L/min. Significant changes in metabolic or ventilatory threshold were not seen for the subjects in the placebo group after 12 weeks, and there were no changes in V̇o2 max in either group.
Conclusion: This pilot study suggests that supplementation with Cs-4 (Cordyceps sinensis) improves exercise performance and might contribute to wellness in healthy older subjects.

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Published In

cover image The Journal of Alternative and Complementary Medicine
The Journal of Alternative and Complementary Medicine
Volume 16Issue Number 5May 2010
Pages: 585 - 590
PubMed: 20804368

History

Published online: 18 May 2010
Published in print: May 2010

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    Authors

    Affiliations

    Steve Chen, M.D.
    Center for Human Nutrition, University of California, Los Angeles, Los Angeles, CA.
    Zhaoping Li, M.D., Ph.D.
    Center for Human Nutrition, University of California, Los Angeles, Los Angeles, CA.
    Robert Krochmal, M.D.
    Center for Human Nutrition, University of California, Los Angeles, Los Angeles, CA.
    Marlon Abrazado, B.S.
    Exercise Physiology Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
    Woosong Kim, B.S.
    Center for Human Nutrition, University of California, Los Angeles, Los Angeles, CA.
    Christopher B. Cooper, M.D.
    Exercise Physiology Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.

    Notes

    Address correspondence to:Christopher B. Cooper, M.D.Exercise Physiology Research LaboratoryDepartments of Medicine and PhysiologyDavid Geffen School of MedicineUniversity of California, Los Angeles10833 Le Conte Avenue, 37-131 CHSLos Angeles, CA 90095E-mail: [email protected]

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    No competing financial interests exist.

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