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Published Online: 18 January 2019

Traditional Use of Chinese Herbal Medicine for Insomnia and Priorities Setting of Future Clinical Research

Publication: The Journal of Alternative and Complementary Medicine
Volume 25, Issue Number 1

Abstract

Objectives: To evaluate the traditional use of Chinese herbal medicine (CHM) for insomnia in pre-contemporary times.
Materials and methods: The Encyclopedia of Traditional Chinese Medicine (fifth edition) was systematically searched using seven Chinese medicine disease nomenclatures to identify insomnia citations. Citations were coded, and frequently used herbal formulae specific for insomnia were analyzed.
Results: Insomnia treatments were mentioned in 940 citations, and insomnia diagnosis treated with Chinese herbal formulae was specifically described in 800 citations. The traditional use of CHM appeared to be individualized based on the cause, pathogenesis, phase, phenotype, demographics, and concurrent medical conditions of insomnia. The most common herbal formulae for insomnia included Wen dan tang, Suan zao ren tang, Ban xia shu mi tang, and Gui pi tang. The most frequently cited herb was suan zao ren (Ziziphi spinosae semen).
Conclusions: A number of herbal formulae for insomnia were cited in the historical literature. The commonly cited formulae such as Wen dan tang and Suan zao ren tang are consistent with current clinical practice and are good prospects for further therapeutic development.

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References

1. Cunnington D, Junge M. Chronic insomnia: Diagnosis and non-pharmacological management. BMJ 2016;355:i5819.
2. Wu MH, Wang XY, eds. Internal Medicine of Chinese Medicine, National Higher Education Textbook of Chinese Medicine [全国中医药行业高等教育“十二五”规划教材:中医内科学]. Beijing: China Press of Traditional Chinese Medicine, 2012.
3. Maciocia G, ed. The foundations of Chinese medicine: A Comprehensive Text [Internet]. 3rd ed. London: Elsevier Health Sciences, 2015.
4. Li JW, Yu AH, Cai JF, eds. Grand Dictionary of Chinese Medicine 2nd ed. [中医大辞典]. Beijing: People's Medical Publishing House, 2013.
5. Sun GR, ed. Fundamental Theory of Traditional Chinese Medicine, National Higher Education Textbook of Chinese Medicine [新世纪全国高等中医药院校规划教材: 中医基础理论]. Beijing: China Press of Traditional Chinese Medicine, 2002.
6. Huang PX, Huang Y, eds. Clinical Diagnosis and Treatment for Neurological Conditions in Chinese Medicine [专科专病中医临床诊治丛书:神经科专病中医临床诊治]. Beijing: People's Medical Publishing House, 2013.
7. Liu YJ, Gao RL, eds. Sleep Medicine of Chinese Medicine [中医睡眠医学]. Beijing: People's Medical Publishing house, 2003.
8. O'Brien K, Weber D. Insomnia in Chinese medicine: The heart of the matter. J Altern Complement Med 2016;22:684–694.
9. Ni X, Shergis JL, Guo X, et al. Updated clinical evidence of Chinese herbal medicine for insomnia: A systematic review and meta-analysis of randomized controlled trials. Sleep Med 2015;16:1462–1481.
10. Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med 2011;17:1217–1220.
11. May BH, Lu Y, Lu C, et al. Systematic assessment of the representativeness of published collections of the traditional literature on Chinese medicine. J Altern Complement Med 2013;19: 403–409.
12. May BH, Zhang A, Lu Y, et al. The systematic assessment of traditional evidence from the premodern Chinese medical literature: A text-mining approach. J Altern Complement Med 2014;20:937–942.
13. May BH, Lu C, Bennett L, et al. Evaluating the traditional Chinese literature for herbal formulae and individual herbs used for age-related dementia and memory impairment. Biogerontology 2012;13:299–312.
14. Zhang L, Li Y, Guo X, et al. Text mining of the classical medical literature for medicines that show potential in diabetic nephropathy. Evid Based Complement Altern Med 2014;2014:189–125.
15. Shergis JL, Wu L, May BH, et al. Natural products for chronic cough: Text mining the East Asian historical literature for future therapeutics. Chron Respir Dis 2015;12:204–211.
16. Sun HS, Yan JL. Origin of disease name referring to Insomnia in Chinese medicine [不寐病名考略]. Chinese J Med History 2004;34:214–217.
17. Zhang JY, Chen PP. Exploration of ancient literature on insomnia [失眠病证古代文献探微]. Shanghai J Tradit Chin Med 2012;46:17–19.
18. Ma Jie, Li F, Song YH. Archaeological study of insomnia in chinese medicine [失眠症中医学溯源与思考]. Forum Tradit Chin Med 2012;27:15–16.
19. Xia ZN, Chen ZL, eds. Comprehensive Chinese Dictionary [辞海缩印版]. Shanghai: Shanghai Lexicographical Publishing House, 2010.
20. Lin ZG, ed. Great Dictionary of Comparisons between Chinese and Western Medical Terms [中西医病名对照大辞典]. Beijing: People's Health Publishing House, 2002.
21. Zhu WF, ed. Conventional Procedures of Diagnosis and Treatment for Internal Medicine in Chinese Medicine, National Standards and Applications. 1st ed. [中医内科疾病诊疗常规, 第一版]. Changsha: Hunan Science and Technology Press, 1999.
22. China Association of Chinese Medicine. Symptoms in Chinese Medicine, Guidelines for Diagnosis and Treatment of Common Internal Disease in Chinese Medicine [中医内科常见病诊疗指南]. Beijing: China Press of Traditional Chinese Medicine, 2008.
23. Chinese Academy of Chinese Medical Sciences. Internal Medicine, Evidence-based Guidelines of Clinical Practice in Chinese Medicine [中医循证临床实践指南.中医内科]. Beijing: Chinese Press of Traditional Chinese Medicine, 2011.
24. Ling XS, ed. Integrative Chinese and Western Medicine [中西医结合内科学]. Beijing: China Press of Traditional Chinese Medicine, 2001.
25. MR C, JL Z, eds. Neurology, Diagnosis and Treatment with Integrative Chinese and Western Medicine [中西医结合专科病诊疗大系: 神经病学]. Taiyuan: Shanxi Publishing House of Science and Technology, 1997.
26. Kong BY, Li J, eds. Integrative Chinese and Western Therapeutics in Neurology [中西医结合神经病治疗学]. Beijing: People's Health Publishing House, 2005.
27. Liu ZF, Tan ZH, eds. Concise Integrative Chinese and Western Therapeutics in Neurology [简明中西医结合神经病学]. Beijing: Scientific and Technical Documentation Press, 2008.
28. Zhou GS, Hu JM, eds. Clinical Psychiatry of Integrative Chinese and Western Medicine. [中西医临床精神病学]. Beijing: China Press of Traditional Chinese Medicine, 1998.
29. Zhang DB, editor. Neurology and Psychiatry in Chinese Medicine [中医神经精神病学]. Beijing: China Medical Science Press, 2000.
30. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing, 2013.
31. Chinese Pharmacopoeia Commission. Pharmacopoeia of People's Republic of China (2015) [中华人民共和国药典 (2015)]. Beijing: China Medical Science Press, 2015.
32. Luo J, Zhu G, Zhao Q, et al. Prevalence and risk factors of poor sleep quality among Chinese elderly in an urban community: Results from the Shanghai aging study. PLoS One 2013;8:e81261.
33. Lu AP, Jia HW, Xiao C, et al. Theory of traditional Chinese medicine and therapeutic method of diseases. World J Gastroenterol 2004;10:1854–1856.
34. Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin J Integr Med 2012;18:883–890.
35. Zhang R, Yang YS, Liu XC, et al. Correlation study of basic Chinese medicine syndromes and neurotransmitter levels in patients with primary insomnia. Chin J Integr Med.
36. Jiang L, Liu B, Xie Q, et al. Investigation into the influence of physician for treatment based on syndrome differentiation. Evid Based Complement Altern Med 2013;2013:587234.
37. Yeung WF, Chung KF, Poon MM, et al. Prescription of Chinese herbal medicine and selection of acupoints in pattern-based traditional Chinese medicine treatment for insomnia: A systematic review. Evid Based Complement Altern Med 2012;2012:902578.
38. Nong TQ. The effect of Banxia Shumi decoction on space learning and memory ability in radial maze of the rat model of sleep deprivation [半夏秫米汤对小站台水环境睡眠剥夺大鼠八臂迷宫空间学习记忆能力的影响]. J Pract Tradit Chin Intern Med 2012;26:36–38.
39. Scheid V, Bensky D, Ellis A, Barolet R, eds. Chinese Herbal Medicine: Formulas & Strategies. 2nd ed. Seattle, WA: Eastland Press, 2009.
40. Wang L, Song Y, Li F, et al. Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin. Neural Regen Res 2014;9:205–212.
41. Wu F, Song Y, Li F, et al. Wen-dan decoction improves negative emotions in sleep-deprived rats by regulating orexin-a and leptin expression. Evid Based Complement Altern Med 2014;2014:872547.
42. Dan Bensky, editor. Chinese Herbal Medicine: Materia Medica, 3rd ed. Seattle, WA: Eastland Press, Inc., 2004.
43. Wu XY, Zhao JL, Zhang M, et al. Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum. J Ethnopharmacol 2011;135:325–329.
44. Li GX, Liu YJ, Hong L, et al. Wen dan ning xin granule in the treatment of primary insomnia: A clinical study. Beijing J Tradit Chin Med 2013;32:775–777.
45. Peng HR, ed. Great Compendium of Chinese Medicine Formulae [中医方剂大辞典]. Beijing: People's Medical Publishing House, 1997.
46. Li YJ, Bi KS. Study on the therapeutic material basis of traditional Chinese medicinal preparation Suanzaoren decoction. Chem Pharm Bull (Tokyo) 2006;54:847–851.
47. Chen CY, Chen YF, Tsai HY. What is the effective component in suanzaoren decoction for curing insomnia? Discovery by virtual screening and molecular dynamic simulation. J Biomol Struct Dyn 2008;26:57–64.
48. Li Y, Liang X, Xiao H, Bi K. Determination of spinosin in rat plasma by reversed-phase high-performance chromatography after oral administration of Suanzaoren decoction. J Chromatogr B Analyt Technol Biomed Life Sci 2003;787:421–425.
49. Yi PL, Lin CP, Tsai CH, et al. The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. J Biomed Sci 2007;14:829–840.
50. Yi PL, Tsai CH, Chen YC, Chang FC. Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration. J Biomed Sci 2007;14:285–297.
51. Chen HC, Hsieh MT. Clinical trial of suanzaorentang in the treatment of insomnia. Clin Ther 1985;7:334–337.
52. Xie CL, Gu Y, Wang WW, et al. Efficacy and safety of Suanzaoren decoction for primary insomnia: A systematic review of randomized controlled trials. BMC Complement Altern Med 2013;13:18.
53. Chan YY, Chen YH, Yang SN, et al. Clinical efficacy of traditional Chinese Medicine, Suan Zao Ren Tang, for sleep disturbance during methadone maintenance: A randomized, double-blind, placebo-controlled trial. Evid Based Complement Altern Med 2015;2015:710895.
54. Yeh CH, Arnold CK, Chen YH, Lai JN. Suan zao ren tang as an original treatment for sleep difficulty in climacteric women: A prospective clinical observation. Evid Based Complement Altern Med 2011;2011:673813.
55. Liu QQ, Zhang J, Guo RJ, et al. Efficacy and safety of the Chaihuguizhiganjiang-suanzaoren granule on primary insomnia: Study protocol for a randomised controlled trial. BMJ Open 2016;6:e008459.
56. Yan S, Zhang R, Zhou X, et al. Exploring effective core drug patterns in primary insomnia treatment with Chinese herbal medicine: Study protocol for a randomized controlled trial. Trials 2013;14:61.

Information & Authors

Information

Published In

cover image The Journal of Alternative and Complementary Medicine
The Journal of Alternative and Complementary Medicine
Volume 25Issue Number 1January 2019
Pages: 8 - 15
PubMed: 30376350

History

Published online: 18 January 2019
Published in print: January 2019
Published ahead of print: 30 October 2018

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Affiliations

Xiaojia Ni
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
Johannah Linda Shergis
School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
Anthony Lin Zhang
School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
Xinfeng Guo
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chuanjian Lu
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yan Li
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Charlie Changli Xue [email protected]
Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.

Notes

Address correspondence to: Charlie Changli Xue, PhD, School of Health and Biomedical Sciences, RMIT University, PO BOX 71, Bundoora VIC 3083, Australia [email protected]

Authors' Contributions

X.N. conceived the study, coded the citations, and wrote the article. X.N. and J.L.S. designed the study and analyzed the data. A.L.Z., X.G., C.L., and Y.L. contributed to data interpretation. C.C.X. contributed to the overall design, quality control, and data interpretation. All authors critically reviewed the article and approved the submission.

Author Disclosure Statement

No competing financial interests exist.

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