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Published Online: 12 September 2022

The Impact of Frailty on All-Cause Mortality in Patients with HIV Infection: A Systematic Review and Meta-Analysis

Publication: AIDS Research and Human Retroviruses
Volume 38, Issue Number 9

Abstract

The aim of this study was to conduct a systematic review and meta-analysis of cohort studies that have examined the association between frailty and all-cause mortality in patients with HIV infection. We searched Embase, Medline through the Ovid interface, PubMed, Cochrane Library, and Web of Science to identify potential studies. Cohort studies of death outcomes in HIV patients under debilitating conditions were included and other ineligible or inadequate data were excluded. Data related to all-cause mortality in patients with HIV were extracted. The quality of the included studies was assessed using the Newcastle–Ottawa Scale for cohort studies. Hazard ratios (HRs) and their 95% confidence intervals (CIs) were pooled to estimate the association between frailty and all-cause mortality using Stata, version 12.0. We identified 845 unduplicated citations. Of these, six cohort studies were eligible for inclusion in the review after applying our inclusion and exclusion criteria. Pooled results demonstrated that patients with HIV experiencing frailty were at an increased risk of all-cause mortality (pooled HR = 2.69, 95% CI = 1.83–3.97, p < .001) compared with those without frailty. Frailty was significantly associated with an increased risk of all-cause mortality among patients with HIV, indicating that frailty is an important predictor of adverse clinical outcomes. Therefore, more attention should be paid to screen patients with HIV for frailty and adopt appropriate interventions and personalized treatment plans to prevent the occurrence of adverse events. However, these results need to be validated in further prospective cohort studies in ethnically or geographically diverse populations.

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cover image AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses
Volume 38Issue Number 9September 2022
Pages: 692 - 699
PubMed: 35658605

History

Published online: 12 September 2022
Published in print: September 2022
Published ahead of print: 1 August 2022
Published ahead of production: 4 June 2022

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Authors

Affiliations

Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Qiao Yan
Clinical Trial Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Mengmeng Xiao
Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Jing Zhao
Center of Infectious Diseases, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Ying Wang
Center of Infectious Diseases, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Rong Deng
Center of Infectious Diseases, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Cong Wang
Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
Zhibo Yang
Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.

Notes

Address correspondence to: Yan Jiang, Evidence-based Nursing Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan 610041, China [email protected]

Authors' Contributions

S.L. was involved in conceptualization, methodology, data curation, formal analysis, writing—original draft, and writing—review and editing. Q.Y. was involved in methodology, conceptualization, and writing—review and editing. Y.J. was involved in conceptualization, methodology, writing—review and editing, and supervision. M.X. and J.Z. were involved in methodology and literature screening. Y.W. was involved in writing—review and editing, and supervision. R.D. was involved in data extraction and analysis. C.W. was involved in methodology, data extraction and analysis, and writing—review and editing. Z.Y. was involved in writing—review and editing.

Author Disclosure Statement

The authors report no conflicts of interest.

Funding Information

The work was supported, in part, by the West China Nursing Discipline Development Special Fund Project, Sichuan University (HXHL19035).

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