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Published Online: 2 March 2010

Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies

Publication: Antioxidants & Redox Signaling
Volume 12, Issue Number 7

Abstract

Selenium (Se), in the form of the 21st amino acid selenocysteine, is an integral part of selenoproteins and essential for mammals. While a large number of health claims for Se has been proposed in a diverse set of diseases, little is known about the precise molecular mechanisms and the physiological roles of selenoproteins. With the recent and rigorous application of reverse genetics in the mouse, great strides have been made to address this on a more molecular level. In this review, we focus on results obtained from the application of mouse molecular genetics in mouse physiology and discuss these insights into the physiological actions of selenoproteins in light of evidence from human genetics. Antioxid. Redox Signal. 12, 851–865.

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References

1.
Aoyama KSuh SWHamby AMLiu JChan WYChen YSwanson RA. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouseNat Neurosci9119-1262006. 1. Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, and Swanson RA. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci 9: 119–126, 2006.
2.
Beck MALevander OAHandy J. Selenium deficiency and viral infectionJ Nutr1331463S-1467S2003. 2. Beck MA, Levander OA, and Handy J. Selenium deficiency and viral infection. J Nutr 133: 1463S–1467S, 2003.
3.
Behne DHilmert HScheid SGessner HElger W. Evidence for specific selenium target tissues and new biologically important selenoproteinsBiochim Biophys Acta96612-211988. 3. Behne D, Hilmert H, Scheid S, Gessner H, and Elger W. Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta 966: 12–21, 1988.
4.
Bermano GNicol FDyer JASunde RABeckett GJArthur JRHesketh JE. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in ratsBiochem J311425-4301995. 4. Bermano G, Nicol F, Dyer JA, Sunde RA, Beckett GJ, Arthur JR, and Hesketh JE. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochem J 311: 425–430, 1995.
5.
Blankenberg SRupprecht HJBickel CTorzewski MHafner GTiret LSmieja MCambien FMeyer JLackner KJ. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery diseaseN Engl J Med3491605-16132003. 5. Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, and Lackner KJ. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 349: 1605–1613, 2003.
6.
Blauwkamp MNYu JSchin MABurke KABerry MJCarlson BABrosius FC 3rdKoenig RJ. Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 miceBMC Nephrol972008. 6. Blauwkamp MN, Yu J, Schin MA, Burke KA, Berry MJ, Carlson BA, Brosius FC, 3rd, and Koenig RJ. Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice. BMC Nephrol 9: 7, 2008.
7.
Bondareva AACapecchi MRIverson SVLi YLopez NILucas OMerrill GFPrigge JRSiders AMWakamiya MWallin SLSchmidt EE. Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptomeFree Radic Biol Med43911-9232007. 7. Bondareva AA, Capecchi MR, Iverson SV, Li Y, Lopez NI, Lucas O, Merrill GF, Prigge JR, Siders AM, Wakamiya M, Wallin SL, and Schmidt EE. Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. Free Radic Biol Med 43: 911–923, 2007.
8.
Boonplueang RAkopian GStevenson FFKuhlenkamp JFLu SCWalsh JPAndersen JK. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell deathExp Neurol192203-2142005. 8. Boonplueang R, Akopian G, Stevenson FF, Kuhlenkamp JF, Lu SC, Walsh JP, and Andersen JK. Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death. Exp Neurol 192: 203–214, 2005.
9.
Burk RFHill KE. Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasisAnnu Rev Nutr25215-2352005. 9. Burk RF and Hill KE. Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr 25: 215–235, 2005.
10.
Burk RFHill KEAwad JAMorrow JDLyons PR. Liver and kidney necrosis in selenium-deficient rats depleted of glutathioneLab Invest72723-7301995. 10. Burk RF, Hill KE, Awad JA, Morrow JD, and Lyons PR. Liver and kidney necrosis in selenium-deficient rats depleted of glutathione. Lab Invest 72: 723–730, 1995.
11.
Burk RFHill KEMotley AKAustin LMNorsworthy BK. Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium contentBiochim Biophys Acta17601789-17932006. 11. Burk RF, Hill KE, Motley AK, Austin LM, and Norsworthy BK. Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium content. Biochim Biophys Acta 1760: 1789–1793, 2006.
12.
Burk RFHill KEOlson GEWeeber EJMotley AKWinfrey VPAustin LM. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fedJ Neurosci276207-62112007. 12. Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, Winfrey VP, and Austin LM. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J Neurosci 27: 6207–6211, 2007.
13.
Carlson BASchweizer UPerella CShrimali RKFeigenbaum LShen LSperansky SFloss TJeong SJWatts JHoffmann VCombs GFGladyshev VNHatfield DL. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of miceBiochem J41861-712009. 13. Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, and Hatfield DL. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Biochem J 418: 61–71, 2009.
14.
Carlson BAXu XMGladyshev VNHatfield DL. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNAJ Biol Chem2805542-55482005. 14. Carlson BA, Xu XM, Gladyshev VN, and Hatfield DL. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem 280: 5542–5548, 2005.
15.
Chu FFEsworthy RSChu PGLongmate JAHuycke MMWilczynski SDoroshow JH. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genesCancer Res64962-9682004. 15. Chu FF, Esworthy RS, Chu PG, Longmate JA, Huycke MM, Wilczynski S, and Doroshow JH. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res 64: 962–968, 2004.
16.
Clark LCCombs GF Jr.Turnbull BWSlate EHChalker DKChow JDavis LSGlover RAGraham GFGross EGKrongrad ALesher JL Jr.Park HKSanders BB Jr.Smith CLTaylor JR. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study GroupJAMA2761957-19631996. 16. Clark LC, Combs GF, Jr., Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL, Jr., Park HK, Sanders BB, Jr., Smith CL, and Taylor JR. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276: 1957–1963, 1996.
17.
Conrad M. Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4Biochim Biophys Acta17901575-15852009. 17. Conrad M. Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4. Biochim Biophys Acta 1790: 1575–1585, 2009.
18.
Conrad MJakupoglu CMoreno SGLippl SBanjac ASchneider MBeck HHatzopoulos AKJust USinowatz FSchmahl WChien KRWurst WBornkamm GWBrielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart functionMol Cell Biol249414-94232004. 18. Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, and Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol 24: 9414–9423, 2004.
19.
Conrad MMoreno SGSinowatz FUrsini FKolle SRoveri ABrielmeier MWurst WMaiorino MBornkamm GW. The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stabilityMol Cell Biol257637-76442005. 19. Conrad M, Moreno SG, Sinowatz F, Ursini F, Kolle S, Roveri A, Brielmeier M, Wurst W, Maiorino M, and Bornkamm GW. The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Mol Cell Biol 25: 7637–7644, 2005.
20.
Conrad MSchneider MSeiler ABornkamm GW. Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammalsBiol Chem3881019-10252007. 20. Conrad M, Schneider M, Seiler A, and Bornkamm GW. Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals. Biol Chem 388: 1019–1025, 2007.
21.
Crack PJCimdins KAli UHertzog PJIannello RC. Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neuronsJ Neural Transm113645-6572006. 21. Crack PJ, Cimdins K, Ali U, Hertzog PJ, and Iannello RC. Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons. J Neural Transm 113: 645–657, 2006.
22.
Davis CDZeng HFinley JW. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia miceJ Nutr132307-3092002. 22. Davis CD, Zeng H, and Finley JW. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia mice. J Nutr 132: 307–309, 2002.
23.
de Haan JBStefanovic NNikolic–Paterson DScurr LLCroft KDMori TAHertzog PKola IAtkins RCTesch GH. Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathyAm J Physiol Renal Physiol289F544-5512005. 23. de Haan JB, Stefanovic N, Nikolic–Paterson D, Scurr LL, Croft KD, Mori TA, Hertzog P, Kola I, Atkins RC, and Tesch GH. Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Renal Physiol 289: F544–551, 2005.
24.
de Haan JBWitting PKStefanovic NPete JDaskalakis MKola IStocker RSmolich JJ. Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat dietJ Lipid Res471157-11672006. 24. de Haan JB, Witting PK, Stefanovic N, Pete J, Daskalakis M, Kola I, Stocker R, and Smolich JJ. Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. J Lipid Res 47: 1157–1167, 2006.
25.
Deniziak MThisse CRederstorff MHindelang CThisse BLescure A. Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryoExp Cell Res313156-1672007. 25. Deniziak M, Thisse C, Rederstorff M, Hindelang C, Thisse B, and Lescure A. Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Exp Cell Res 313: 156–167, 2007.
862
26.
Diwadkar–Navsariwala VPrins GSSwanson SMBirch LARay VHHedayat SLantvit DLDiamond AM. Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic modelProc Natl Acad Sci USA1038179-81842006. 26. Diwadkar–Navsariwala V, Prins GS, Swanson SM, Birch LA, Ray VH, Hedayat S, Lantvit DL, and Diamond AM. Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. Proc Natl Acad Sci USA 103: 8179–8184, 2006.
27.
Downey CMHorton CRCarlson BAParsons TEHatfield DLHallgrimsson BJirik FR. Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: A putative model for Kashin–Beck diseasePLoS Genetics5e10006162009. 27. Downey CM, Horton CR, Carlson BA, Parsons TE, Hatfield DL, Hallgrimsson B, and Jirik FR. Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: A putative model for Kashin–Beck disease. PLoS Genetics 5: e1000616, 2009.
28.
Dumitrescu AMLiao XHAbdullah MSLado–Abeal JMajed FAMoeller LCBoran GSchomburg LWeiss RERefetoff S. Mutations in SECISBP2 result in abnormal thyroid hormone metabolismNat Genet371247-12522005. 28. Dumitrescu AM, Liao XH, Abdullah MS, Lado–Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, and Refetoff S. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat Genet 37: 1247–1252, 2005.
29.
Esworthy RSAranda RMartin MGDoroshow JHBinder SWChu FF. Mice with combined disruption of Gpx1 and Gpx2 genes have colitisAm J Physiol Gastrointest Liver Physiol281G848-8552001. 29. Esworthy RS, Aranda R, Martin MG, Doroshow JH, Binder SW, and Chu FF. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol 281: G848–855, 2001.
30.
Esworthy RSYang LFrankel PHChu FF. Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient miceJ Nutr135740-7452005. 30. Esworthy RS, Yang L, Frankel PH, and Chu FF. Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. J Nutr 135: 740–745, 2005.
31.
Felix KGerstmeier SKyriakopoulos AHoward OMDong HFEckhaus MBehne DBornkamm GWJanz S. Selenium deficiency abrogates inflammation-dependent plasma cell tumors in miceCancer Res642910-29172004. 31. Felix K, Gerstmeier S, Kyriakopoulos A, Howard OM, Dong HF, Eckhaus M, Behne D, Bornkamm GW, and Janz S. Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice. Cancer Res 64: 2910–2917, 2004.
32.
Ferguson ADLabunskyy VMFomenko DEArac DChelliah YAmezcua CARizo JGladyshev VNDeisenhofer J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like familyJ Biol Chem2813536-35432006. 32. Ferguson AD, Labunskyy VM, Fomenko DE, Arac D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, and Deisenhofer J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem 281: 3536–3543, 2006.
33.
Flohe L. Selenium in mammalian spermiogenesisBiol Chem388987-9952007. 33. Flohe L. Selenium in mammalian spermiogenesis. Biol Chem 388: 987–995, 2007.
34.
Flohe LGunzler WASchock HH. Glutathione peroxidase: A selenoenzymeFEBS Lett32132-1341973. 34. Flohe L, Gunzler WA, and Schock HH. Glutathione peroxidase: A selenoenzyme. FEBS Lett 32: 132–134, 1973.
35.
Fomenko DENovoselov SVNatarajan SKLee BCKoc ACarlson BALee THKim HYHatfield DLGladyshev VN. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein formJ Biol Chem2845986-59932009. 35. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, and Gladyshev VN. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem 284: 5986–5993, 2009.
36.
Forgione MAWeiss NHeydrick SCap AKlings ESBierl CEberhardt RTFarber HWLoscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunctionAm J Physiol Heart Circ Physiol282H1255-12612002. 36. Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, and Loscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 282: H1255–1261, 2002.
37.
Galton VASchneider MJClark ASSt Germain DL. Life without thyroxine to 3,5,3'-triiodothyronine conversion: studies in mice devoid of the 5'-deiodinasesEndocrinology1502957-29632009. 37. Galton VA, Schneider MJ, Clark AS, and St Germain DL. Life without thyroxine to 3,5,3'-triiodothyronine conversion: studies in mice devoid of the 5'-deiodinases. Endocrinology 150: 2957–2963, 2009.
38.
Gao JXiong YHo YSLiu XChua CCXu XWang HHamdy RChua BH. Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicityBiochim Biophys Acta17832020-20292008. 38. Gao J, Xiong Y, Ho YS, Liu X, Chua CC, Xu X, Wang H, Hamdy R, and Chua BH. Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity. Biochim Biophys Acta 1783: 2020–2029, 2008.
39.
Garry MRKavanagh TJFaustman EMSidhu JSLiao RWare CVliet PADeeb SS. Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stressFree Radic Biol Med441075-10872008. 39. Garry MR, Kavanagh TJ, Faustman EM, Sidhu JS, Liao R, Ware C, Vliet PA, and Deeb SS. Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress. Free Radic Biol Med 44: 1075–1087, 2008.
40.
Ge KXue ABai JWang S. Keshan disease. An endemic cardiomyopathy in ChinaVirchows Arch A Pathol Anat Histopathol4011-151983. 40. Ge K, Xue A, Bai J, and Wang S. Keshan disease. An endemic cardiomyopathy in China. Virchows Arch A Pathol Anat Histopathol 401: 1–15, 1983.
41.
Geisberger RKiermayer CHomig CConrad MSchmidt JZimber–Strobl UBrielmeier M. B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenanceBiol Chem3881083-10902007. 41. Geisberger R, Kiermayer C, Homig C, Conrad M, Schmidt J, Zimber–Strobl U, and Brielmeier M. B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Biol Chem 388: 1083–1090, 2007.
42.
Gladyshev VNJeang KTStadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental geneProc Natl Acad Sci USA936146-61511996. 42. Gladyshev VN, Jeang KT, and Stadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci USA 93: 6146–6151, 1996.
43.
Gromer SJohansson LBauer HArscott LDRauch SBallou DPWilliams CH Jr.Schirmer RHArner ES. Active sites of thioredoxin reductases: why selenoproteins?Proc Natl Acad Sci USA10012618-126232003. 43. Gromer S, Johansson L, Bauer H, Arscott LD, Rauch S, Ballou DP, Williams CH, Jr., Schirmer RH, and Arner ES. Active sites of thioredoxin reductases: why selenoproteins? Proc Natl Acad Sci USA 100: 12618–12623, 2003.
44.
Gross MOertel MKohrle J. Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1Biochem J306851-8561995. 44. Gross M, Oertel M, and Kohrle J. Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1. Biochem J 306: 851–856, 1995.
45.
Gunn SAGould TCAnderson WA. Incorporation of selenium into spermatogenic pathway in miceProc Soc Exp Biol Med1241260-12631967. 45. Gunn SA, Gould TC, and Anderson WA. Incorporation of selenium into spermatogenic pathway in mice. Proc Soc Exp Biol Med 124: 1260–1263, 1967.
46.
Hernandez AMartinez MEFiering SGalton VASt Germain D. Type 3 deiodinase is critical for the maturation and function of the thyroid axisJ Clin Invest116476-4842006. 46. Hernandez A, Martinez ME, Fiering S, Galton VA, and St Germain D. Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest 116: 476–484, 2006.
47.
Hill KEZhou JAustin LMMotley AKHam AJOlson GEAtkins JFGesteland RFBurk RF. The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body seleniumJ Biol Chem28210972-109802007. 47. Hill KE, Zhou J, Austin LM, Motley AK, Ham AJ, Olson GE, Atkins JF, Gesteland RF, and Burk RF. The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium. J Biol Chem 282: 10972–10980, 2007.
48.
Hill KEZhou JMcMahan WJMotley AKAtkins JFGesteland RFBurk RF. Deletion of selenoprotein P alters distribution of selenium in the mouseJ Biol Chem27813640-136462003. 48. Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, Gesteland RF, and Burk RF. Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem 278: 13640–13646, 2003.
49.
Hill KEZhou JMcMahan WJMotley AKBurk RF. Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P geneJ Nutr134157-1612004. 49. Hill KE, Zhou J, McMahan WJ, Motley AK, and Burk RF. Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J Nutr 134: 157–161, 2004.
50.
Ho YSMagnenat JLBronson RTCao JGargano MSugawara MFunk CD. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxiaJ Biol Chem27216644-166511997. 50. Ho YS, Magnenat JL, Bronson RT, Cao J, Gargano M, Sugawara M, and Funk CD. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 272: 16644–16651, 1997.
51.
Hornberger TAMcLoughlin TJLeszczynski JKArmstrong DDJameson RRBowen PEHwang ESHou HMoustafa MECarlson BAHatfield DLDiamond AMEsser KA. Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growthJ Nutr1333091-30972003. 51. Hornberger TA, McLoughlin TJ, Leszczynski JK, Armstrong DD, Jameson RR, Bowen PE, Hwang ES, Hou H, Moustafa ME, Carlson BA, Hatfield DL, Diamond AM, and Esser KA. Selenoprotein-deficient transgenic mice exhibit enhanced exercise-induced muscle growth. J Nutr 133: 3091–3097, 2003.
52.
Imai HHirao FSakamoto TSekine KMizukura YSaito MKitamoto THayasaka MHanaoka KNakagawa Y. Early embryonic lethality caused by targeted disruption of the mouse PHGPx geneBiochem Biophys Res Commun305278-2862003. 52. Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, Saito M, Kitamoto T, Hayasaka M, Hanaoka K, and Nakagawa Y. Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun 305: 278–286, 2003.
53.
Irons RCarlson BAHatfield DLDavis CD. Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expressionJ Nutr1361311-13172006. 53. Irons R, Carlson BA, Hatfield DL, and Davis CD. Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression. J Nutr 136: 1311–1317, 2006.
54.
Jakupoglu CPrzemeck GKSchneider MMoreno SGMayr NHatzopoulos AKde Angelis MHWurst WBornkamm GWBrielmeier MConrad M. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac developmentMol Cell Biol251980-19882005. 54. Jakupoglu C, Przemeck GK, Schneider M, Moreno SG, Mayr N, Hatzopoulos AK, de Angelis MH, Wurst W, Bornkamm GW, Brielmeier M, and Conrad M. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol 25: 1980–1988, 2005.
863
55.
Jurynec MJXia RMackrill JJGunther DCrawford TFlanigan KMAbramson JJHoward MTGrunwald DJ. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscleProc Natl Acad Sci USA10512485-124902008. 55. Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, Abramson JJ, Howard MT, and Grunwald DJ. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci USA 105: 12485–12490, 2008.
56.
Klein EAThompson IMLippman SMGoodman PJAlbanes DTaylor PRColtman C. SELECT: The next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention TrialJ Urol1661311-13152001. 56. Klein EA, Thompson IM, Lippman SM, Goodman PJ, Albanes D, Taylor PR, and Coltman C. SELECT: The next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial. J Urol 166: 1311–1315, 2001.
57.
Kryukov GVCastellano SNovoselov SVLobanov AVZehtab OGuigo RGladyshev VN. Characterization of mammalian selenoproteomesScience3001439-14432003. 57. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, and Gladyshev VN. Characterization of mammalian selenoproteomes. Science 300: 1439–1443, 2003.
58.
Lin MTBeal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesNature443787-7952006. 58. Lin MT and Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787–795, 2006.
59.
Lippman SMKlein EAGoodman PJLucia MSThompson IMFord LGParnes HLMinasian LMGaziano JMHartline JAParsons JKBearden JD 3rdCrawford EDGoodman GEClaudio JWinquist ECook EDKarp DDWalther PLieber MMKristal ARDarke AKArnold KBGanz PASantella RMAlbanes DTaylor PRProbstfield JLJagpal TJCrowley JJMeyskens FL Jr.Baker LHColtman CA Jr. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)JAMA30139-512009. 59. Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD, 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL, Jr., Baker LH, and Coltman CA, Jr. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301: 39–51, 2009.
60.
Maiorino MBosello VUrsini FForesta CGarolla AScapin MSztajer HFlohe L. Genetic variations of gpx-4 and male infertility in humansBiol Reprod681134-11412003. 60. Maiorino M, Bosello V, Ursini F, Foresta C, Garolla A, Scapin M, Sztajer H, and Flohe L. Genetic variations of gpx-4 and male infertility in humans. Biol Reprod 68: 1134–1141, 2003.
61.
Maiorino MRoveri ABenazzi LBosello VMauri PToppo STosatto SCUrsini F. Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidaseJ Biol Chem28038395-384022005. 61. Maiorino M, Roveri A, Benazzi L, Bosello V, Mauri P, Toppo S, Tosatto SC, and Ursini F. Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase. J Biol Chem 280: 38395–38402, 2005.
62.
Mauri PBenazzi LFlohe LMaiorino MPietta PGPilawa SRoveri AUrsini F. Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MSBiol Chem384575-5882003. 62. Mauri P, Benazzi L, Flohe L, Maiorino M, Pietta PG, Pilawa S, Roveri A, and Ursini F. Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MS. Biol Chem 384: 575–588, 2003.
63.
Moghadaszadeh BPetit NJaillard CBrockington MRoy SQMerlini LRomero NEstournet BDesguerre IChaigne DMuntoni FTopaloglu HGuicheney P. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndromeNat Genet2917-182001. 63. Moghadaszadeh B, Petit N, Jaillard C, Brockington M, Roy SQ, Merlini L, Romero N, Estournet B, Desguerre I, Chaigne D, Muntoni F, Topaloglu H, and Guicheney P. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Nat Genet 29: 17–18, 2001.
64.
Moreno–Reyes RSuetens CMathieu FBegaux FZhu DRivera MTBoelaert MNeve JPerlmutter NVanderpas J. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine statusN Engl J Med3391112-11201998. 64. Moreno–Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Rivera MT, Boelaert M, Neve J, Perlmutter N, and Vanderpas J. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339: 1112–1120, 1998.
65.
Moskovitz JStadtman ER. Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissuesProc Natl Acad Sci USA1007486-74902003. 65. Moskovitz J and Stadtman ER. Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues. Proc Natl Acad Sci USA 100: 7486–7490, 2003.
66.
Ng LGoodyear RJWoods CASchneider MJDiamond ERichardson GPKelley MWGermain DLGalton VAForrest D. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinaseProc Natl Acad Sci USA1013474-34792004. 66. Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, and Forrest D. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci USA 101: 3474–3479, 2004.
67.
Ng LHernandez AHe WRen TSrinivas MMa MGalton VASt Germain DLForrest D. A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory functionEndocrinology1501952-19602009. 67. Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, and Forrest D. A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology 150: 1952–1960, 2009.
68.
Nonn LWilliams RRErickson RPPowis G. The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous miceMol Cell Biol23916-9222003. 68. Nonn L, Williams RR, Erickson RP, and Powis G. The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol 23: 916–922, 2003.
69.
Olson GEWinfrey VPHill KEBurk RF. Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cellsJ Biol Chem2836854-68602008. 69. Olson GE, Winfrey VP, Hill KE, and Burk RF. Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem 283: 6854–6860, 2008.
70.
Olson GEWinfrey VPNagdas SKHill KEBurk RF. Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testisJ Biol Chem28212290-122972007. 70. Olson GE, Winfrey VP, Nagdas SK, Hill KE, and Burk RF. Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis. J Biol Chem 282: 12290–12297, 2007.
71.
Olson GEWinfrey VPNagdas SKHill KEBurk RF. Selenoprotein P is required for mouse sperm developmentBiol Reprod73201-2112005. 71. Olson GE, Winfrey VP, Nagdas SK, Hill KE, and Burk RF. Selenoprotein P is required for mouse sperm development. Biol Reprod 73: 201–211, 2005.
72.
Pfeifer HConrad MRoethlein DKyriakopoulos ABrielmeier MBornkamm GWBehne D. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturationFASEB J151236-12382001. 72. Pfeifer H, Conrad M, Roethlein D, Kyriakopoulos A, Brielmeier M, Bornkamm GW, and Behne D. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. FASEB J 15: 1236–1238, 2001.
73.
Puglisi RBevilacqua ACarlomagno GLenzi AGandini LStefanini MMangia FBoitani C. Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertilityEndocrinology1484302-43092007. 73. Puglisi R, Bevilacqua A, Carlomagno G, Lenzi A, Gandini L, Stefanini M, Mangia F, and Boitani C. Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility. Endocrinology 148: 4302–4309, 2007.
74.
Pushpa–Rekha TRBurdsall ALOleksa LMChisolm GMDriscoll DM. Rat phospholipid-hydroperoxide glutathione peroxidase cDNA cloning and identification of multiple transcription and translation start sitesJ Biol Chem27026993-26999.1995. 74. Pushpa–Rekha TR, Burdsall AL, Oleksa LM, Chisolm GM, and Driscoll DM. Rat phospholipid-hydroperoxide glutathione peroxidase cDNA cloning and identification of multiple transcription and translation start sites. J Biol Chem 270: 26993–26999., 1995.
75.
Rayman MP. The importance of selenium to human healthLancet356233-2412000. 75. Rayman MP. The importance of selenium to human health. Lancet 356: 233–241, 2000.
76.
Renko KHofmann PJStoedter MHollenbach BBehrends TKohrle JSchweizer USchomburg L. Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in miceFASEB J231758-17652009. 76. Renko K, Hofmann PJ, Stoedter M, Hollenbach B, Behrends T, Kohrle J, Schweizer U, and Schomburg L. Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. FASEB J 23: 1758–1765, 2009.
77.
Renko KWerner MRenner–Muller ICooper TGYeung CHHollenbach BScharpf MKohrle JSchomburg LSchweizer U. Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout miceBiochem J409741-7492008. 77. Renko K, Werner M, Renner–Muller I, Cooper TG, Yeung CH, Hollenbach B, Scharpf M, Kohrle J, Schomburg L, and Schweizer U. Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Biochem J 409: 741–749, 2008.
78.
Rotruck JTPope ALGanther HESwanson ABHafeman DGHoekstra WG. Selenium: biochemical role as a component of glutathione peroxidaseScience179588-5901973. 78. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, and Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 179: 588–590, 1973.
79.
This reference has been deleted. 79. This reference has been deleted.
80.
Schneider MForster HBoersma ASeiler AWehnes HSinowatz FNeumuller CDeutsch MJWalch AHrabe de Angelis MWurst WUrsini FRoveri AMaleszewski MMaiorino MConrad M. Mitochondrial glutathione peroxidase 4 disruption causes male infertilityFASEB J233233-32422009. 80. Schneider M, Forster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumuller C, Deutsch MJ, Walch A, Hrabe de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, and Conrad M. Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J 23: 3233–3242, 2009.
81.
Schneider MVogt Weisenhorn DMSeiler ABornkamm GWBrielmeier MConrad M. Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidaseGene Expr Patterns6489-4942006. 81. Schneider M, Vogt Weisenhorn DM, Seiler A, Bornkamm GW, Brielmeier M, and Conrad M. Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase. Gene Expr Patterns 6: 489–494, 2006.
82.
Schneider MJFiering SNPallud SEParlow AFSt Germain DLGalton VA. Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4Mol Endocrinol152137-21482001. 82. Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St Germain DL, and Galton VA. Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4. Mol Endocrinol 15: 2137–2148, 2001.
864
83.
Schneider MJFiering SNThai BWu SYSt Germain EParlow AFSt Germain DLGalton VA. Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in miceEndocrinology147580-5892006. 83. Schneider MJ, Fiering SN, Thai B, Wu SY, St Germain E, Parlow AF, St Germain DL, and Galton VA. Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology 147: 580–589, 2006.
84.
Schomburg LRiese CMichaelis MGriebert EKlein MOSapin RSchweizer UKohrle J. Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic miceEndocrinology1471306-13132006. 84. Schomburg L, Riese C, Michaelis M, Griebert E, Klein MO, Sapin R, Schweizer U, and Kohrle J. Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice. Endocrinology 147: 1306–1313, 2006.
85.
Schomburg LSchweizer U. Hierarchical regulation of selenoprotein expression and sex-specific effects of seleniumBiochim Biophys Acta17901453-14622009. 85. Schomburg L and Schweizer U. Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium. Biochim Biophys Acta 1790: 1453–1462, 2009.
86.
Schomburg LSchweizer UHoltmann BFlohe LSendtner MKohrle J. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissuesBiochem J370397-4022003. 86. Schomburg L, Schweizer U, Holtmann B, Flohe L, Sendtner M, and Kohrle J. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J 370: 397–402, 2003.
87.
Schweizer UBrauer AUKohrle JNitsch RSavaskan NE. Selenium and brain function: A poorly recognized liaisonBrain Res Brain Res Rev45164-1782004. 87. Schweizer U, Brauer AU, Kohrle J, Nitsch R, and Savaskan NE. Selenium and brain function: A poorly recognized liaison. Brain Res Brain Res Rev 45: 164–178, 2004.
88.
Schweizer UChiu JKohrle J. Peroxides and peroxide-degrading enzymes in the thyroidAntioxid Redox Signal101577-15922008. 88. Schweizer U, Chiu J, and Kohrle J. Peroxides and peroxide-degrading enzymes in the thyroid. Antioxid Redox Signal 10: 1577–1592, 2008.
89.
Schweizer UMichaelis MKohrle JSchomburg L. Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiencyBiochem J37821-262004. 89. Schweizer U, Michaelis M, Kohrle J, and Schomburg L. Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency. Biochem J 378: 21–26, 2004.
90.
Schweizer USchomburg L. New insights into the physiological actions of selenoproteins from genetically modified miceIUBMB Life57737-7442005. 90. Schweizer U and Schomburg L. New insights into the physiological actions of selenoproteins from genetically modified mice. IUBMB Life 57: 737–744, 2005.
91.
Schweizer USchomburg L. Selenium, selenoproteins and brain functionSelenium: Its Molecular Biology and Role in Human HealthHatfield DLBerry MJGladyshev VNNew YorkSpringer2006233-248. 91. Schweizer U and Schomburg L. Selenium, selenoproteins and brain function. In: Selenium: Its Molecular Biology and Role in Human Health, edited by Hatfield DL, Berry MJ, and Gladyshev VN. New York: Springer, 2006, pp. 233–248.
92.
Schweizer UStreckfuss FPelt PCarlson BAHatfield DLKohrle JSchomburg L. Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supplyBiochem J386221-2262005. 92. Schweizer U, Streckfuss F, Pelt P, Carlson BA, Hatfield DL, Kohrle J, and Schomburg L. Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. Biochem J 386: 221–226, 2005.
93.
Schweizer UWeitzel JMSchomburg L. Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmasMol Cell Endocrinol2891-92008. 93. Schweizer U, Weitzel JM, and Schomburg L. Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas. Mol Cell Endocrinol 289: 1–9, 2008.
94.
Seiler ASchneider MForster HRoth SWirth EKCulmsee CPlesnila NKremmer ERadmark OWurst WBornkamm GWSchweizer UConrad M. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell deathCell Metab8237-2482008. 94. Seiler A, Schneider M, Forster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Radmark O, Wurst W, Bornkamm GW, Schweizer U, and Conrad M. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 8: 237–248, 2008.
95.
Sengupta ACarlson BAHoffmann VJGladyshev VNHatfield DL. Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolismBiochem Biophys Res Commun365446-4522008. 95. Sengupta A, Carlson BA, Hoffmann VJ, Gladyshev VN, and Hatfield DL. Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun 365: 446–452, 2008.
96.
Shi ZZOsei–Frimpong JKala GKala SVBarrios RJHabib GMLukin DJDanney CMMatzuk MMLieberman MW. Glutathione synthesis is essential for mouse development but not for cell growth in cultureProc Natl Acad Sci U S A975101-51062000. 96. Shi ZZ, Osei–Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, and Lieberman MW. Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A 97: 5101–5106, 2000.
97.
Shrimali RKIrons RDCarlson BASano YGladyshev VNPark JMHatfield DL. Selenoproteins mediate T cell immunity through an antioxidant mechanismJ Biol Chem28320181-201852008. 97. Shrimali RK, Irons RD, Carlson BA, Sano Y, Gladyshev VN, Park JM, and Hatfield DL. Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem 283: 20181–20185, 2008.
98.
Shrimali RKWeaver JAMiller GFStarost MFCarlson BANovoselov SVKumaraswamy EGladyshev VNHatfield DL. Selenoprotein expression is essential in endothelial cell development and cardiac muscle functionNeuromuscul Disord17135-1422007. 98. Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, and Hatfield DL. Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord 17: 135–142, 2007.
99.
Soerensen JJakupoglu CBeck HForster HSchmidt JSchmahl WSchweizer UConrad MBrielmeier M. The role of thioredoxin reductases in brain developmentPLoS ONE3e18132008. 99. Soerensen J, Jakupoglu C, Beck H, Forster H, Schmidt J, Schmahl W, Schweizer U, Conrad M, and Brielmeier M. The role of thioredoxin reductases in brain development. PLoS ONE 3: e1813, 2008.
100.
Stone R. Diseases. A medical mystery in middle ChinaScience3241378-13812009. 100. Stone R. Diseases. A medical mystery in middle China. Science 324: 1378–1381, 2009.
101.
Streckfuss FHamann ISchomburg LMichaelis MSapin RKlein MOKohrle JSchweizer U. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in miceBiochem Biophys Res Commun337739-7452005. 101. Streckfuss F, Hamann I, Schomburg L, Michaelis M, Sapin R, Klein MO, Kohrle J, and Schweizer U. Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice. Biochem Biophys Res Commun 337: 739–745, 2005.
102.
Su DNovoselov SVSun QAMoustafa MEZhou YOko RHatfield DLGladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturationJ Biol Chem28026491-264982005. 102. Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, and Gladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem 280: 26491–26498, 2005.
103.
Suppmann SPersson BCBock A. Dynamics and efficiency in vivo of UGA-directed selenocysteine insertion at the ribosomeEMBO J182284-22931999. 103. Suppmann S, Persson BC, and Bock A. Dynamics and efficiency in vivo of UGA-directed selenocysteine insertion at the ribosome. EMBO J 18: 2284–2293, 1999.
104.
Torzewski MOchsenhirt VKleschyov ALOelze MDaiber ALi HRossmann HTsimikas SReifenberg KCheng FLehr HABlankenberg SForstermann UMunzel TLackner KJ. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient miceArterioscler Thromb Vasc Biol27850-8572007. 104. Torzewski M, Ochsenhirt V, Kleschyov AL, Oelze M, Daiber A, Li H, Rossmann H, Tsimikas S, Reifenberg K, Cheng F, Lehr HA, Blankenberg S, Forstermann U, Munzel T, and Lackner KJ. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27: 850–857, 2007.
105.
Ursini FHeim SKiess MMaiorino MRoveri AWissing JFlohe L. Dual function of the selenoprotein PHGPx during sperm maturationScience2851393-13961999. 105. Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J, and Flohe L. Dual function of the selenoprotein PHGPx during sperm maturation. Science 285: 1393–1396, 1999.
106.
Ursini FMaiorino MValente MFerri LGregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxidesBiochim Biophys Acta710197-211.1982. 106. Ursini F, Maiorino M, Valente M, Ferri L, and Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochim Biophys Acta 710: 197–211., 1982.
107.
Valentine WMHill KEAustin LMValentine HLGoldowitz DBurk RF. Brainstem axonal degeneration in mice with deletion of selenoprotein pToxicol Pathol33570-5762005. 107. Valentine WM, Hill KE, Austin LM, Valentine HL, Goldowitz D, and Burk RF. Brainstem axonal degeneration in mice with deletion of selenoprotein p. Toxicol Pathol 33: 570–576, 2005.
108.
van Leyen KKim HYLee SRJin GArai KLo EH. Baicalein and 12/15-lipoxygenase in the ischemic brainStroke373014-30182006. 108. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, and Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 37: 3014–3018, 2006.
109.
Wallace E. CGW, and Calvin H. L. Effects of selenium deficiency on the shape and arrangement of rodent sperm mitochondriaGamete Res4389-3991983. 109. Wallace E. CGW, and Calvin H. L. Effects of selenium deficiency on the shape and arrangement of rodent sperm mitochondria. Gamete Res 4: 389–399, 1983.
110.
Watanabe TEndo A. Effects of selenium deficiency on sperm morphology and spermatocyte chromosomes in miceMutat Res26293-991991. 110. Watanabe T and Endo A. Effects of selenium deficiency on sperm morphology and spermatocyte chromosomes in mice. Mutat Res 262: 93–99, 1991.
111.
Weiss NZhang YYHeydrick SBierl CLoscalzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunctionProc Natl Acad Sci USA9812503-125082001. 111. Weiss N, Zhang YY, Heydrick S, Bierl C, and Loscalzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc Natl Acad Sci USA 98: 12503–12508, 2001.
112.
Whanger PD. Selenoprotein expression and function. Selenoprotein WBiochim Biophys Acta17901448-14522009. 112. Whanger PD. Selenoprotein expression and function. Selenoprotein W. Biochim Biophys Acta 1790: 1448–1452, 2009.
113.
Wong CHBozinovski SHertzog PJHickey MJCrack PJ. Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusionJ Neurochem107241-2522008. 113. Wong CH, Bozinovski S, Hertzog PJ, Hickey MJ, and Crack PJ. Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion. J Neurochem 107: 241–252, 2008.
865
114.
Xu XMCarlson BAMix HZhang YSaira KGlass RSBerry MJGladyshev VNHatfield DL. Biosynthesis of selenocysteine on its tRNA in eukaryotesPLoS Biol5e42007. 114. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, and Hatfield DL. Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol 5: e4, 2007.
115.
Yant LJRan QRao LVan Remmen HShibatani TBelter JGMotta LRichardson AProlla TA. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insultsFree Radic Biol Med34496-5022003. 115. Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, Motta L, Richardson A, and Prolla TA. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med 34: 496–502, 2003.
116.
Ye YShibata YYun CRon DRapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolNature429841-8472004. 116. Ye Y, Shibata Y, Yun C, Ron D, and Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429: 841–847, 2004.

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cover image Antioxidants & Redox Signaling
Antioxidants & Redox Signaling
Volume 12Issue Number 7April 1, 2010
Pages: 851 - 865
PubMed: 19803749

History

Published in print: April 1, 2010
Published online: 2 March 2010
Published ahead of print: 11 January 2010
Published ahead of production: 5 October 2009
Accepted: 5 October 2009
Received: 21 September 2009

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Marcus Conrad
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
Ulrich Schweizer
Neurobiology of Selenium, Neuroscience Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Notes

Address correspondence to:Dr. Marcus ConradInstitute of Clinical Molecular Biology and Tumor Genetics
Helmholtz Zentrum MünchenGerman Research Center for Environmental HealthMarchioninistr. 2581377 MunichGermany
E-mail: [email protected]

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No competing financial interests exist.

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