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Published Online: 7 May 2012

Role of Cystathionine γ-Lyase/Hydrogen Sulfide Pathway in Cardiovascular Disease: A Novel Therapeutic Strategy?

Publication: Antioxidants & Redox Signaling
Volume 17, Issue Number 1

Abstract

Significance: Hydrogen sulfide (H2S) has traditionally been considered a toxic environmental pollutant. In the late 1990s, the presumed solely harmful role of H2S has been challenged because H2S may also be involved in the maintenance and preservation of cardiovascular homeostasis. Recent Advances: The production of endogenous H2S has been attributed to three key enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase. The recognition of H2S as the third gaseous signaling molecule has stimulated research on a multitude of pathophysiologic events in the cardiovascular system. In particular, important roles in cardiovascular disorder processes are ascribed to the CSE/H2S pathway, such as atherosclerosis, myocardial infarction, hypertension, and shock. Critical Issues: Many biological activities and molecular mechanisms of H2S in the cardiovascular system have been demonstrated in studies using different tools, such as the genetic overexpression of CSE, the direct administration of H2S donors, or the use of H2S-releasing pro-drugs. Unfortunately, the role of the CSE/H2S pathway in cardiovascular disease remains controversial in numerous areas, and many questions regarding the gaseous molecule still remain unanswered. Future Directions: Advances in basic research indicate that the CSE/H2S pathway may provide potential therapeutic targets for treating cardiovascular disorders. But the molecular targets of H2S still need to be identified. Antioxid. Redox Signal. 17, 106–118.

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cover image Antioxidants & Redox Signaling
Antioxidants & Redox Signaling
Volume 17Issue Number 1July 1, 2012
Pages: 106 - 118
PubMed: 22017202

History

Published in print: July 1, 2012
Published online: 7 May 2012
Published ahead of print: 25 January 2012
Published ahead of production: 21 October 2011
Accepted: 21 October 2011
Received: 19 October 2011

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Li Long Pan
*
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Xin Hua Liu*
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Qi Hai Gong
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
He Bei Yang
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Yi Zhun Zhu
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Department of Pharmacology, National University of Singapore, Singapore, Singapore.

Notes

Address correspondence to:Prof. Yi Zhun Zhu826 ZhangHeng RoadShanghai, 201203China
E-mail: [email protected] [email protected]

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No conflicts to disclose.

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