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Published Online: 20 April 2018

Does Fluoroscopy Induce DNA Oxidative Damage in Patients Undergoing Catheter Ablation?

Publication: Antioxidants & Redox Signaling
Volume 28, Issue Number 12

Abstract

As no studies before now have thoroughly investigated the risk associated with the exposure to low-dose ionizing radiations in patients undergoing catheter ablation (CA), we aimed to evaluate the oxidative and DNA damage in 59 CA patients (10 of whom received N-acetylcysteine (NAC) before the procedure). A burst of oxidized/reduced glutathione ratio was observed 3 hours after procedure that was diminished by NAC administration. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) concentrations, index of oxidative DNA damage, showed a peak 24 hours after CA. A positive correlation between 8-OHdG peak and fluoroscopy time and a negative correlation among 8-OHdG decrease (from the peak to 48 hours after CA) and all procedure parameters were found. Furthermore, DNA tail percentages (which reflect the extent and the number of DNA strand breaks) positively correlated with 8-OHdG concentrations. This study evaluates for the first time the kinetic of oxidative damage in patients undergoing CA procedure. Our findings raise the question of whether 8-OHdG can be used as a circulating biomarker of DNA oxidative damage induced by low-dose ionizing radiations in different clinical settings. Antioxid. Redox Signal. 28, 1137–1143.

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Information & Authors

Information

Published In

cover image Antioxidants & Redox Signaling
Antioxidants & Redox Signaling
Volume 28Issue Number 12April 20, 2018
Pages: 1137 - 1143
PubMed: 28938845

History

Published in print: April 20, 2018
Published online: 20 April 2018
Published ahead of print: 27 November 2017
Published ahead of production: 22 September 2017
Accepted: 16 September 2017
Received: 12 September 2017

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    Authors

    Affiliations

    Linda Turnu*
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.
    Benedetta Porro*
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Valentina Alfieri
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.
    Alessandro Di Minno
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.
    Eleonora Russo
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Simone Barbieri
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Alice Bonomi
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Antonio Dello Russo
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Claudio Tondo
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Yuri D'Alessandra
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Viviana Cavalca
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Elena Tremoli
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Gualtiero I. Colombo
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.
    Michela Casella
    Centro Cardiologico Monzino, IRCCS, Milan, Italy.

    Notes

    *
    These authors contributed equally to this work.
    Address correspondence to:Dr. Alessandro Di MinnoCentro Cardiologico MonzinoIRCCSVia C. Parea 4Milan 20138Italy
    E-mail: [email protected]

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