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Published Online: 21 October 2011

MRI Diffusion Indices Sampled Along Streamline Trajectories: Quantitative Tractography Mapping

Publication: Brain Connectivity
Volume 1, Issue Number 4

Abstract

Several useful tractography-derived maps have recently been introduced, such as track density imaging (TDI) and the average pathlength map (APM). Here, an extension to these techniques is introduced by sampling diffusion indices along streamline trajectories (DIST). With this approach, voxels contain summary information of diffusivity measures within streamlines. The diffusion metrics can also be used as weighting factors for streamline number or length, generating DIST-weighted TDI and DIST-weighted APM, respectively. Furthermore, when higher-order models of diffusion are used to estimate the fiber orientation distribution within each voxel, it is possible to obtain directional TDI, APM, DIST, and DIST-weighted TDI and APM. The reproducibility of this approach using two b-values (1000 and 3000 s/mm2) and the effect of pathologic abnormalities are demonstrated.

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Information & Authors

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Published In

cover image Brain Connectivity
Brain Connectivity
Volume 1Issue Number 42011
Pages: 331 - 338
PubMed: 22432422

History

Published online: 21 October 2011
Published ahead of print: 18 October 2011
Published in print: 2011
Published ahead of production: 13 September 2011

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Kerstin Pannek
The University of Queensland, Centre for Clinical Research, Brisbane, Australia.
The University of Queensland, School of Medicine, Brisbane, Australia.
The University of Queensland, Centre for Advanced Imaging, Brisbane, Australia.
Jane L. Mathias
University of Adelaide, School of Psychology, Adelaide, Australia.
Stephen E. Rose
The University of Queensland, Centre for Clinical Research, Brisbane, Australia.
The University of Queensland, School of Medicine, Brisbane, Australia.
The University of Queensland, Centre for Medical Diagnostic Technologies in Queensland, Brisbane, Australia.

Notes

Address correspondence to:Stephen E. RoseThe University of Queensland Centre for Clinical ResearchBuilding 71/918, RBWHHerston, QLD 4029Australia
E-mail: [email protected]

Author Disclosure Statement

No competing financial interests exist.

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