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Published Online: 5 April 2019

Dynamic Functional Network Connectivity in Schizophrenia with Magnetoencephalography and Functional Magnetic Resonance Imaging: Do Different Timescales Tell a Different Story?

Publication: Brain Connectivity
Volume 9, Issue Number 3

Abstract

The importance of how brain networks function together to create brain states has become increasingly recognized. Therefore, an investigation of eyes-open resting-state dynamic functional network connectivity (dFNC) of healthy controls (HC) versus that of schizophrenia patients (SP) via both functional magnetic resonance imaging (fMRI) and a novel magnetoencephalography (MEG) pipeline was completed. The fMRI analysis used a spatial independent component analysis (ICA) to determine the networks on which the dFNC was based. The MEG analysis utilized a source space activity estimate (minimum norm estimate [MNE]/dynamic statistical parametric mapping [dSPM]) whose result was the input to a spatial ICA, on which the networks of the MEG dFNC were based. We found that dFNC measures reveal significant differences between HC and SP, which depended on the imaging modality. Consistent with previous findings, a dFNC analysis predicated on fMRI data revealed HC and SP remain in different overall brain states (defined by a k-means clustering of network correlations) for significantly different periods of time, with SP spending less time in a highly connected state. The MEG dFNC, in contrast, revealed group differences in more global statistics: SP changed between meta-states (k-means cluster states that are allowed to overlap in time) significantly more often and to states that were more different, relative to HC. MEG dFNC also revealed a highly connected state where a significant difference was observed in interindividual variability, with greater variability among SP. Overall, our results show that fMRI and MEG reveal between-group functional connectivity differences in distinct ways, highlighting the utility of using each of the modalities individually, or potentially a combination of modalities, to better inform our understanding of disorders such as schizophrenia.

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cover image Brain Connectivity
Brain Connectivity
Volume 9Issue Number 3April 2019
Pages: 251 - 262
PubMed: 30632385

History

Published online: 5 April 2019
Published in print: April 2019
Published ahead of production: 11 January 2019

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Lori Sanfratello [email protected]
The Mind Research Network, Albuquerque, New Mexico.
Jon M. Houck
The Mind Research Network, Albuquerque, New Mexico.
Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, New Mexico.
Vince D. Calhoun
The Mind Research Network, Albuquerque, New Mexico.
Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, New Mexico.
Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico.

Notes

Address correspondence to: Lori Sanfratello, The Mind Research Network, 1101 Yale Boulevard Northeast, Albuquerque, NM 87016 [email protected]

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No competing financial interests exist.

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