The Application of Dose-Rate Volume Histograms and Survival Fractions to Multicellular Dosimetry
Publication: Cancer Biotherapy & Radiopharmaceuticals
Volume 20, Issue Number 1
Abstract
The distribution of therapeutic radiopharmaceuticals in volumes smaller than those that can be fully resolved by the imaging system, such as by PET and SPECT scanners, is usually assumed to be homogeneous. The aim of this study was to investigate the implications of such an assumption at a scale that can be defined as multicellular for heterogeneous activity localizations of 32P, 90Y, and 131I. Dose-rate distributions from heterogeneous radioactivity uptakes have been calculated in cubic volumes of 1, 3, and 4 mm using the in-house software package DOVE. These have been studied by the use of dose-rate volume histograms, and the influence of the heterogeneous dose distribution on the treatment outcome has been analyzed by the calculation of Integral Survival Fractions. The results showed that the effect of the heterogeneous localization of the compound can be overridden by the amount of radioactivity administered. However, significant variations in the survival probability distributions have been observed, depending on the amount of initial activity considered, the activity configuration, the radionuclide, and the time over which the energy was deposited. It has been shown, for example, that the ability of longer-range beta emitters, such as 32P and 90Y, to invalidate heterogeneous dose-rate distributions may be negated by the decay rate of the radioactivity.
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Published In
Cancer Biotherapy & Radiopharmaceuticals
Volume 20 • Issue Number 1 • February 2005
Pages: 58 - 65
PubMed: 15778582
Copyright
Copyright 2005, Mary Ann Liebert, Inc.
History
Published online: 18 March 2005
Published in print: February 2005
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