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Published Online: 25 February 2008

High-Resolution, Hand-Held Camera for Sentinel-Node Detection

Publication: Cancer Biotherapy & Radiopharmaceuticals
Volume 23, Issue Number 1

Abstract

Background: The imaging probe (IP) is a high-resolution (HR), 1-in2 field-of-view hand-held gamma camera. We used it to detect breast cancer sentinel node (SN). Patients and Methods: We divided 120 T1 breast cancer patients, who underwent Anger camera lymphoscintigraphy (ACL), in two subgroups of 60 patients who were age, body mass index, and cancer size matched: subgroup A (SA) and B (SB). SN was detected with a common gamma probe (GP) in SA, with IP plus GP in SB. Results: Surgeons removed radioactive nodes without exceeding four nodes. Eighty-two (82) SNs were taken off in SA and 105 in SB (p < 0.01). Of SA, 22 of 60 patients and 36 of 60 patients of SB showed more than 1 node, and 3 of them showed 3 nodes and 1 showed 4 nodes. Thirteen (13) patients resulted N+ (21.6%) in SA. Ten (10) patients of SA showed an invasion on the hottest nodes and 3 on the second nodes. In the SB, 18 patients (25%) showed invasion. Sixteen (16) invasions were on hot, 4 on second, and 1 on the third node. Withdrawal time of SN was 11.25 ± 4.7 minutes for SA and 7.4 ± 2.8 minutes for SB (p < 0.025). Conclusions: SN biopsy with IP is fast and discovers more SNs and more invasions than ACL.

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cover image Cancer Biotherapy and Radiopharmaceuticals
Cancer Biotherapy & Radiopharmaceuticals
Volume 23Issue Number 1February 2008
Pages: 43 - 52
PubMed: 18298328

History

Published online: 25 February 2008
Published in print: February 2008

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    Francesco Scopinaro
    Department of Radiological Sciences, “La Sapienza” University, Rome, Italy
    Anna Tofani
    Sant' Andrea Hospital, Rome, Italy
    Gianpaolo di Santo
    Department of Radiological Sciences, “La Sapienza” University, Rome, Italy
    Barbara Di Pietro
    Department of Radiological Sciences, “La Sapienza” University, Rome, Italy
    Augusto Lombardi
    Department of Surgery, “La Sapienza” University, Rome, Italy
    Marzia Lo Russo
    Department of Surgery, “La Sapienza” University, Rome, Italy
    Alessandro Soluri
    Instituto di Ingegnaria Biomedica, Consiglio Nazionale Ricerche, Roma, Italy
    Roberto Massari
    Instituto di Ingegnaria Biomedica, Consiglio Nazionale Ricerche, Roma, Italy
    Carlo Trotta
    Instituto di Ingegnaria Biomedica, Consiglio Nazionale Ricerche, Roma, Italy
    Claudio Amanti
    Department of Surgery, “La Sapienza” University, Rome, Italy

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