Research Article
No access
Published Online: 23 April 2014

Accuracy and Acceptability of the 6-Day Enlite Continuous Subcutaneous Glucose Sensor

Publication: Diabetes Technology & Therapeutics
Volume 16, Issue Number 5


Objective: This study evaluated the performance and acceptability of the Enlite® glucose sensor (Medtronic MiniMed, Inc., Northridge, CA).
Subjects and Methods: Ninety adults with type 1 or type 2 diabetes wore two Enlite sensors on the abdomen and/or buttock for 6 days and calibrated them at different frequencies. On Days 1, 3, and 6, accuracy was evaluated by comparison of sensor glucose values with frequently sampled plasma glucose values collected over a 12-h period. Accuracy was assessed at different reference glucose concentrations and during times when absolute glucose concentration rates of change were <1, 1–2, and >2 mg/dL/min. The sensor's ability to detect hypoglycemia or hyperglycemia was evaluated with simulated alerts. Subject satisfaction was evaluated with a 7-point Likert-type questionnaire, with a score of 7 indicating strong agreement.
Results: With abdomen sensors under actual-use calibration (mean, 2.8±0.9 times/day), the overall mean (median) absolute relative difference (ARD) values between sensor and reference values were 13.6% (10.1%); the corresponding buttock sensor ARD values were 15.5% (10.5%). With abdomen sensors under minimal calibration (mean, 1.2±0.9 times/day), the mean (median) ARD values were 14.7% (10.8%). Mean ARD values of abdomen sensors at rates of change of <1, 1–2, and >2 mg/dL/min were 13.6%, 12.9%, and 16.3%, respectively. With abdomen sensors, 79.5% and 94.1% of hypoglycemic and hyperglycemic events, respectively, were correctly detected; 81.9% and 94.9% of hypoglycemic and hyperglycemic alerts, respectively, were confirmed. The failure rates for abdomen and buttock sensors were 19.7% and 13.9%, respectively. Mean responses to survey questions for all subjects related to comfort and ease of use were favorable.
Conclusions: The Enlite sensor provided accurate data at different glucose concentrations and rates of change. Subjects found the sensor comfortable and easy to use.

Get full access to this article

View all available purchase options and get full access to this article.


Keenan DB, Mastrototaro JJ, Zisser H, Cooper KA, Raghavendhar G, Lee SW, Yusi J, Bailey TS, Brazg RL, Shah RV: Accuracy of the Enlite 6-day glucose sensor with Guardian and Veo calibration algorithms. Diabetes Technol Ther 2012;14:225–231.
Zijlstra E, Heise T, Nosek L, Heinemann L, Heckermann S: Continuous glucose monitoring: quality of hypoglycaemia detection. Diabetes Obes Metab 2013;15:130–135.
Calhoun P, Lum J, Beck RW, Kollman C: Performance comparison of the Medtronic Sof-Sensor and Enlite glucose sensors in inpatient studies of individuals with type 1 diabetes. Diabetes Technol Ther 2013;15:758–761.
Luijf YM, Mader JK, Doll W, Pieber T, Farret A, Place J, Renard E, Bruttomesso D, Filippi A, Avogaro A, Arnolds S, Benesch C, Heinemann L, DeVries JH; AP@Home Consortium: Accuracy and reliability of continuous glucose monitoring systems: a head-to-head comparison. Diabetes Technol Ther 2013;15:722–727.
Slover RH, Welsh JB, Criego A, Weinzimer SA, Willi SM, Wood MA, Tamborlane WV: Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 Study. Pediatr Diabetes 2012;13:6–11.
Ramchandani N, Arya S, Ten S, Bhandari S: Real-life utilization of real-time continuous glucose monitoring: the complete picture. J Diabetes Sci Technol 2011;5:860–870.
Bergenstal RM, Klonoff DC, Garg SK, Bode BW, Meredith M, Slover RH, Ahmann AJ, Welsh JB, Lee SW, Kaufman FR; ASPIRE In-Home Study Group: Threshold-based insulin-pump interruption for reduction of hypoglycemia. N Engl J Med 2013;369:224–232.

Information & Authors


Published In

cover image Diabetes Technology & Therapeutics
Diabetes Technology & Therapeutics
Volume 16Issue Number 5May 2014
Pages: 277 - 283
PubMed: 24758729


Published in print: May 2014
Published online: 23 April 2014
Published ahead of print: 7 April 2014


Request permissions for this article.




Timothy S. Bailey, MD
AMCR Institute, Escondido, California.
Andrew Ahmann, MD
Oregon Health and Sciences University, Portland, Oregon.
Ronald Brazg, MD
Rainier Clinical Research Center, Renton, Washington.
Mark Christiansen, MD
Diablo Clinical Research, Walnut Creek, California.
Satish Garg, MD
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado.
Elaine Watkins, DO, MSPH
Profil Institute for Clinical Research, Chula Vista, California.
John B. Welsh, MD, PhD
Medtronic MiniMed, Northridge, California.
Scott W. Lee, MD
Medtronic MiniMed, Northridge, California.


This study is registered at with clinical trial registration number NCT01464346.
Portions of this work were presented at the 72nd Scientific Sessions of the American Diabetes Association, held in Philadelphia, Pennsylvania, June 8–12, 2012, the 21st Annual Scientific and Clinical Congress of the American Association of Clinical Endocrinologists, held in Philadelphia, Pennsylvania, May 23–27, 2012, and the 48th Annual Meeting of the European Association for the Study of Diabetes, held in Berlin, Germany, October 1–5, 2012.
Address correspondence to:John B. Welsh, MD, PhDMedtronic MiniMed, Inc.18000 Devonshire StreetNorthridge, CA 91325E-mail: [email protected]

Author Disclosure Statement

T.S.B., A.A., R.B., M.C., S.G., and E.W. have received research support from Medtronic, Inc. T.S.B. has received research support from Abbott, ACON, Alere, Animas, BD, Dexcom, Insulet, Lifescan, Lilly, and Tandem and has received consulting honoraria from Bayer, BD, and Medtronic, Inc. J.B.W. and S.W.L. are employees of Medtronic, Inc.

Metrics & Citations



Export citation

Select the format you want to export the citations of this publication.

View Options

Get Access

Access content

To read the fulltext, please use one of the options below to sign in or purchase access.

Society Access

If you are a member of a society that has access to this content please log in via your society website and then return to this publication.

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

View options


View PDF/ePub

Full Text

View Full Text







Copy the content Link

Share on social media

Back to Top