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Published Online: 25 March 2009

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

Publication: DNA and Cell Biology
Volume 11, Issue Number 1

ABSTRACT

The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for undertanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.

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cover image DNA and Cell Biology
DNA and Cell Biology
Volume 11Issue Number 1JAN./FEB. 1992
Pages: 1 - 20
PubMed: 1310857

History

Published online: 25 March 2009
Published in print: JAN./FEB. 1992

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