Abstract
Background: The hypoxia-inducible factor 1 alpha (HIF-1α) plays a major role in cancer progression. Aim: The aim of this study was to investigate the potential association between HIF-1α C1772T gene polymorphism and glioma risk. Methods: We conducted a hospital-based case–control study from China. A total of 300 subjects (150 glioma patients and 150 healthy controls) were recruited in this study. The peripheral blood samples were extracted. The polymerase chain reaction–restriction fragment length polymorphism method was used to test genotypes. Results: Glioma patients had a significantly lower frequency of CC genotype (odds ratio [OR] = 0.46, 95% confidence interval [CI] = 0.24, 0.91; p = 0.03) and C allele (OR = 0.49, 95% CI = 0.26, 0.91; p = 0.03) than controls. Glioma patients had a significantly higher frequency of CT genotype (OR = 2.13, 95% CI = 1.07, 4.25; p = 0.03) and T allele (OR = 2.05, 95% CI = 1.09, 3.83; p = 0.03) than controls. There were no significant differences in the distributions of HIF-1α C1772T gene polymorphism among glioma patients at different tumor type and stage. Conclusion: This study suggested that CT genotype and the T allele of HIF-1α C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China.
