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Published Online: 1 October 2016

Evolution of Hereditary Breast Cancer Genetic Services: Are Changes Reflected in the Knowledge and Clinical Practices of Florida Providers?

Publication: Genetic Testing and Molecular Biomarkers
Volume 20, Issue Number 10

Abstract

Aims: We describe practitioner knowledge and practices related to hereditary breast and ovarian cancer (HBOC) in an evolving landscape of genetic testing. Methods: A survey was mailed in late 2013 to Florida providers who order HBOC testing. Descriptive statistics were conducted to characterize participants' responses. Results: Of 101 respondents, 66% indicated either no genetics education or education through a commercial laboratory. Although 79% of respondents were aware of the Supreme Court ruling resulting in the loss of Myriad Genetics' BRCA gene patent, only 19% had ordered testing from a different laboratory. With regard to pretest counseling, 78% of respondents indicated they usually discuss 11 of 14 nationally recommended elements for informed consent. Pretest discussion times varied from 3 to 120 min, with approximately half spending <20 min. Elements not routinely covered by >40% of respondents included (1) possibility of a variant of uncertain significance (VUS) and (2) issues related to life/disability insurance. With regard to genetic testing for HBOC, 88% would test an unaffected sister of a breast cancer patient identified with a BRCA VUS. Conclusions: Results highlight the need to identify whether variability in hereditary cancer service delivery impacts patient outcomes. Findings also reveal opportunities to facilitate ongoing outreach and education.

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Published In

cover image Genetic Testing and Molecular Biomarkers
Genetic Testing and Molecular Biomarkers
Volume 20Issue Number 10October 2016
Pages: 569 - 578
PubMed: 27525501

History

Published in print: October 2016
Published online: 1 October 2016
Published ahead of print: 15 August 2016

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Deborah Cragun
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Department of Global Health, University of South Florida, Tampa, Florida.
Courtney Scherr
Department of Communication Studies, Northwestern University, Chicago, Illinois.
Lucia Camperlengo
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Susan T. Vadaparampil
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Tuya Pal
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Notes

Address correspondence to:Tuya Pal, MDDepartment of Cancer EpidemiologyH. Lee Moffitt Cancer Center and Research Institute12902 Magnolia DriveMRC-CANCONTTampa, FL 33612E-mail: [email protected]

Author Disclosure Statement

No competing financial interests exist.

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