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Published Online: 14 February 2023

Ultra-Late Osteosarcoma Recurrences: An Analysis of 17 Cooperative Osteosarcoma Study Group Patients with a First Recurrence Detected More Than 10 Years After Primary Tumor Diagnosis

Publication: Journal of Adolescent and Young Adult Oncology
Volume 12, Issue Number 1

Abstract

Purpose: Osteosarcoma is a typical malignancy of childhood and adolescence. Recurrences usually occur early, but rarely may arise after decades of remission. Little is known about these very late events and we set out to fill this knowledge gap.
Methods: The database of the Cooperative Osteosarcoma Study Group (COSS) was searched for patients with a first recurrence of a high-grade central osteosarcoma occurring >10 years after diagnosis of the primary disease. Identified patients were analyzed for demographic, tumor-, and treatment-related factors as well as outcomes.
Results: Among a total of 1,178 10-year relapse-free survivors, 17 affected patients were identified. Only five of these had a documented good response to initial chemotherapy. No presenting factor was identified to predict these very late events. Prognosis was generally very poor despite intensive multimodal therapy. Inoperability of the recurrences seems to have constituted a major limiting factor.
Conclusion: Osteosarcoma patients should be followed for potential recurrences for well >10 years from initial diagnosis. Only through such an extended truly long-term follow-up and a structured transition of young patients can these be detected while they are still operable and, hence, potentially curable.

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cover image Journal of Adolescent and Young Adult Oncology
Journal of Adolescent and Young Adult Oncology
Volume 12Issue Number 1February 2023
Pages: 76 - 82
PubMed: 36454220

History

Published online: 14 February 2023
Published in print: February 2023
Published ahead of print: 28 November 2022

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Stefanie Hecker-Nolting
Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Leo Kager
Department of Pediatrics, Medical University Vienna and St. Anna Children's Cancer Research Institute (CCRI), St. Anna Children's Hospital, Vienna, Austria.
Thomas Kühne
Department of Oncology/Hematology, University Children's Hospital Basel, Basel, Switzerland.
Daniel Baumhoer
Bone Tumor Reference Center, Institute of Medical Genetics and Pathology, University Hospital Basel and University of Basel, Basel, Switzerland.
Claudia Blattmann
Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Godehard Friedel
Clinic for Thoracic, Heart and Vascular Surgery, University Hospital Tuebingen, Tuebingen, Germany.
Thekla von Kalle
Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Radiologic Institute, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Mathias Kevric
Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Regine Mayer-Steinacker
Division of Hematology and Oncology, Department of Internal Medicine, Ulm University Hospital, Ulm, Germany.
Rudolf Schwarz
Department of Radiation Oncology, University Medical Center Eppendorf, Hamburg, Germany.
Benjamin Sorg
Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Thomas Wirth
Department of Orthopaedics, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Stuttgart, Germany.
Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.

Notes

Address correspondence to: Stefan S. Bielack, MD, Cooperative Osteosarcoma Study Group, Pediatrics 5 (Oncology, Hematology, Immunology), Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart—Olgahospital, Kriegsbergstr. 62, Stuttgart 70174, Germany [email protected]

Author Disclosure Statement

L.K. reports having acted as advisory board member for Amgen, Agios, Bayer, and Novartis. T.W. reports grants from Orthopediatrics and Orthofix. S.S.B. reports having acted as consultant and/or advisory board member for Bayer Healthcare, Boehringer Ingelheim, Hoffmann-La Roche, Ipsen, and Eli Lilly. All these financial relationships were outside the scope of submitted study. S.H.-N., T.K., D.B., C.B., G.F., T.v.K., M.K., R.M.-S., R.S., and B.S. report no conflicts of interest.

Funding Information

The studies from which these patients originate were supported by Deutsche Krebshilfe (DKH T10/96/Bi, DKH 70-02160, DKH 50-2723-Bi2), Deutsche Forschungsgemeinschaft (BI 1045/1-1, BI 1045/1–2), Fördergemeinschaft Kinderkrebs-Zentrum Hamburg, and Förderkreis krebskranke Kinder Stuttgart.

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