Interferon-Stimulated Gene 15 and the Protein ISGylation System
Publication: Journal of Interferon & Cytokine Research
Volume 31, Issue Number 1
Abstract
Interferon-stimulated gene 15 (ISG15) is one of the most upregulated genes upon Type I interferon treatment or pathogen infection. Its 17 kDa protein product, ISG15, was the first ubiquitin-like modifier identified, and is similar to a ubiquitin linear dimer. As ISG15 modifies proteins in a similar manner to ubiquitylation, protein conjugation by ISG15 is termed ISGylation. Some of the primary enzymes that promote ISGylation are also involved in ubiquitin conjugation. The process to remove ISG15 from its conjugated proteins, termed de-ISGylation, is performed by a cellular ISG15-specific protease, ubiquitin-specific proteases with molecular mass 43 kDa (UBP43)/ubiquitin-specific proteases 18. Relative to ubiquitin, the biological function of ISG15 is still poorly understood, but ISG15 appears to play important roles in various biological and cellular functions. Therefore, there is growing interest in ISG15, as the study of free ISG15 and functional consequences of ISGylation/de-ISGylation may identify useful therapeutic targets. This review highlights recent discoveries and remaining questions important to understanding the biological functions of ISG15.
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Information & Authors
Information
Published In
Journal of Interferon & Cytokine Research
Volume 31 • Issue Number 1 • January 2011
Pages: 119 - 130
PubMed: 21190487
Copyright
Copyright 2011, Mary Ann Liebert, Inc.
History
Published online: 12 January 2011
Published in print: January 2011
Published ahead of print: 29 December 2010
Accepted: 11 August 2010
Received: 11 August 2010
Authors
Author Disclosure Statement
No competing financial interests exist.
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