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Published Online: 1 June 2011

Macrophages in Allergic Asthma: Fine-Tuning Their Pro- and Anti-Inflammatory Actions for Disease Resolution

Publication: Journal of Interferon & Cytokine Research
Volume 31, Issue Number 6

Abstract

Macrophages exert prominent effects in the defense of the respiratory tract from airborne pathogens. These cells are specialized to recognize, phagocytose, and destroy these infectious agents and then promote appropriate tissue repair after successful pathogen clearance. For reasons that are not presently clear, macrophages appear to be inappropriately activated during asthma responses. Evidence stems from the appearance of either classically (or M1) and alternatively activated (or M2) cells in the alveolar compartment of asthmatic lung. Macrophages localized in the interstitial area of the lung appear to be less prone to polarization toward either the M1 or M2 phenotype as these cells predominately express interleukin-10 and exhibit immunoregulatory properties. Effective treatment of clinical asthma, regardless of severity, might depend on restoring an appropriate balance between M1, M2, and immunoregulatory macrophages in the lung.

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cover image Journal of Interferon & Cytokine Research
Journal of Interferon & Cytokine Research
Volume 31Issue Number 6June 2011
Pages: 485 - 491
PubMed: 21631355

History

Published in print: June 2011
Published online: 1 June 2011
Accepted: 8 April 2011
Received: 8 April 2011

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    Ana Paula Moreira
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
    Cory M. Hogaboam
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.

    Notes

    Address correspondence to:Prof. Cory M. HogaboamDepartment of PathologyUniversity of Michigan Medical SchoolRoom 4057, BSRB109 Zina Pitcher RoadAnn Arbor, MI 48109-2200E-mail: [email protected]

    Author Disclosure Statement

    No competing financial interests exist.

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