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Published Online: 5 April 2016

STAT5 in Cancer and Immunity

Publication: Journal of Interferon & Cytokine Research
Volume 36, Issue Number 4

Abstract

Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly homologous proteins that are encoded by 2 separate genes and are activated by Janus-activated kinases (JAK) downstream of cytokine receptors. STAT5 proteins are activated by a wide variety of hematopoietic and nonhematopoietic cytokines and growth factors, all of which use the JAK-STAT signalling pathway as their main mode of signal transduction. STAT5 proteins critically regulate vital cellular functions such as proliferation, differentiation, and survival. The physiological importance of STAT5 proteins is underscored by the plethora of primary human tumors that have aberrant constitutive activation of these proteins, which significantly contributes to tumor cell survival and malignant progression of disease. STAT5 plays an important role in the maintenance of normal immune function and homeostasis, both of which are regulated by specific members of IL-2 family of cytokines, which share a common gamma chain (γc) in their receptor complex. STAT5 critically mediates the biological actions of members of the γc family of cytokines in the immune system. Essentially, STAT5 plays a critical role in the function and development of Tregs, and consistently activated STAT5 is associated with a suppression in antitumor immunity and an increase in proliferation, invasion, and survival of tumor cells. Thus, therapeutic targeting of STAT5 is promising in cancer.

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cover image Journal of Interferon & Cytokine Research
Journal of Interferon & Cytokine Research
Volume 36Issue Number 4April 2016
Pages: 226 - 237
PubMed: 26716518

History

Published online: 5 April 2016
Published in print: April 2016
Published ahead of print: 30 December 2015
Received: 16 March 2015
Accepted: 6 November 2014

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Aradhana Rani
Department of Biomedical Sciences, University of Westminster, London, United Kingdom.
John J. Murphy
Department of Biomedical Sciences, University of Westminster, London, United Kingdom.

Notes

Address correspondence to:Dr. Aradhana RaniDepartment of Biomedical SciencesUniversity of WestminsterLondon W1W 6UWUnited Kingdom
E-mail: [email protected]
Dr. John J. MurphyDepartment of Biomedical SciencesUniversity of WestminsterLondon W1W 6UWUnited Kingdom
E-mail: [email protected]

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No competing financial interests exist.

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