Research Article
No access
Published Online: 3 December 2008

Immunological Effects of Yeast- and Mushroom-Derived β-Glucans

Publication: Journal of Medicinal Food
Volume 11, Issue Number 4

ABSTRACT

Glucans have a long history as nonspecific biological modulators. We compared the effects of three different glucans on immune reactions. Using two different administrations (intraperitoneal and oral) and two different animal models, we showed that yeast-derived Betamune™ (Biorigin, São Paulo, Brazil) caused significant stimulation of phagocytic activity as well as potentiation of synthesis and release of interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-13, and tumor necrosis factor-α. In addition, Betamune inhibited growth of tumor cells in vivo and affected expression of several important genes in breast cancer cells. Compared to adult mice, young animals showed different sensitivity to glucan action.

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

cover image Journal of Medicinal Food
Journal of Medicinal Food
Volume 11Issue Number 4December 2008
Pages: 615 - 622
PubMed: 19053851

History

Published online: 3 December 2008
Published in print: December 2008

Permissions

Request permissions for this article.

Authors

Affiliations

Vaclav Vetvicka
Department of Pathology, University of Louisville, Louisville, Kentucky
Aruna Vashishta
Department of Pathology, University of Louisville, Louisville, Kentucky
Sujata Saraswat-Ohri
Department of Pathology, University of Louisville, Louisville, Kentucky
Jana Vetvickova
Department of Pathology, University of Louisville, Louisville, Kentucky

Metrics & Citations

Metrics

Citations

Export citation

Select the format you want to export the citations of this publication.

View Options

Access content

To read the fulltext, please use one of the options below to sign in or purchase access.

Society Access

If you are a member of a society that has access to this content please log in via your society website and then return to this publication.

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

View options

PDF/EPUB

View PDF/EPUB

Figures

Tables

Media

Share

Share

Copy the content Link

Share on social media

Back to Top