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Published Online: 13 December 2012

Anthocyanin-Rich Black Currant Extract and Cyanidin-3-O-Glucoside Have Cytoprotective and Anti-Inflammatory Properties

Publication: Journal of Medicinal Food
Volume 15, Issue Number 12

Abstract

Periodontal diseases are a group of multifactorial polymicrobial infections characterized by a progressive inflammatory destruction of the periodontium. Flavonoids, including anthocyanins, are receiving increasing attention because of their promising human health benefits. The aim of our study was to investigate the effect of anthocyanins, pure or as part of a standardized black currant extract, on nicotine-induced cytotoxicity and lipopolysaccharide (LPS)-induced inflammatory responses in human cells. Using a colorimetric assay that measures cell viability, it was found that a pretreatment with an anthocyanin-rich black currant extract or cyanidin-3-O-glucoside neutralized the cytotoxic effect of nicotine on epithelial cells and fibroblasts in a dose-dependent manner. The black currant extract and cyanidin-3-O-glucoside also inhibited the LPS-induced secretion of interleukin-6 by human macrophages. The results of the present study suggest that black currant extract and cyanidin-3-O-glucoside may be promising candidates for the development of novel therapies to prevent and/or to treat smoking-related periodontal diseases.

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Information & Authors

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Published In

cover image Journal of Medicinal Food
Journal of Medicinal Food
Volume 15Issue Number 12December 2012
Pages: 1045 - 1050
PubMed: 22738124

History

Published online: 13 December 2012
Received: 7 December 2012
Published in print: December 2012
Published ahead of print: 27 June 2012
Accepted: 30 March 2012

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Affiliations

Jacynthe Desjardins
Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec City, Quebec, Canada.
Shinichi Tanabe
Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec City, Quebec, Canada.
Chantal Bergeron
Tom's of Maine, Kennebunk, Maine, USA.
Stefan Gafner
Tom's of Maine, Kennebunk, Maine, USA.
Daniel Grenier
Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec City, Quebec, Canada.

Notes

Address correspondence to: Daniel Grenier, Oral Ecology Research Group, Laval University, 2420 rue de la Terrasse, Quebec City, QC, Canada, G1V 0A6, E-mail: [email protected]

Author Disclosure Statement

C.B. and S.G. are employees of Tom's of Maine. J.D., S.T., and D.G. report no conflicts of interest related to this study.

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