Top Ten Tips Palliative Care Clinicians Should Know About Designing a Clinical Trial in Palliative Care
Publication: Journal of Palliative Medicine
Abstract
The palliative care field is experiencing substantive growth in clinical trial-based research. Randomized controlled trials provide the necessary rigor and conditions for assessing a treatment’s efficacy in a controlled population. It is therefore important that a trial is meticulously designed from the outset to ensure the integrity of the ultimate results. In this article, our team discusses ten tips on clinical trial design drawn from collective experiences in the field. These ten tips cover a range of topics that can prove challenging in trial design, from developing initial methodologies to planning sample size and powering the trial, as well as collaboratively navigating the ethical issues of trial initiation and implementation as a cohesive team. We aim to help new researchers design sound trials and continue to grow the evidence base for our specialty. The guidance provided here can be used independently or in addition to the ten tips provided by this team in a separate article focused on what palliative care clinicians should know about interpreting a clinical trial.
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Information & Authors
Information
Published In
Journal of Palliative Medicine
PubMed: 39167532
Copyright
Copyright 2024, Mary Ann Liebert, Inc., publishers.
History
Published online: 21 August 2024
Accepted: 26 June 2024
Topics
Authors
Author Disclosure Statement
D.H. is supported in part by grants from the National Cancer Institute (R01CA214960, R01CA225701, R01CA231471). W.E.R. is partially supported by the NIH/NCI Comprehensive Cancer Center award number P30CA008748. S.Y. – Grant to institution: Pfizer (cachexia study). T.G., J.H., and P.G. – supported in part by Mater Foundation.
Funding Information
D.H. is supported in part by grants from the National Cancer Institute (R01CA214960, R01CA225701, R01CA231471). W.E.R. is partially supported by the NIH/NCI Comprehensive Cancer Center award number P30CA008748.
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