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Published Online: 25 July 2007

Prevalence, Antimicrobial Resistance, and Extended-Spectrum β-Lactamases Characterization of Salmonella Isolates in Apulia, Southern Italy (2001–2005)

Publication: Microbial Drug Resistance
Volume 13, Issue Number 2

Abstract

The prevalence, antimicrobial susceptibility, and production of extended-spectrum β-lactamases (ESBLs) of Salmonella collected from several hospitals in Apulia (southern Italy) were evaluated. The most common Salmonella isolates were Salmonella enterica serovar Typhimurium (44.6%), S. enterica serovar Enteritidis (33.4 %), S. enterica serovar Infantis (3.2 %), S. enterica serovar Typhi (1.5%), and S. enterica serovar Bovismorbificans (1.5%). The other serovars accounted for less than 1% each. Our data show a high resistance to ampicillin, tetracycline, and chloramphenicol. The isolates were pansensitive (53.5%), resistant to one antimicrobial agent (10.5%), resistant to two antimicrobial agents (22.1%), resistant to three antimicrobial agents (10.8%), and to four antimicrobial agents (2.7%). Resistance to more than four antibiotics was observed in 0.5% of strains. The presence of ESBL was found in only one strain of S. enterica serovar Bovismorbificans. The CTX-M-1 type-producing strain was identified by isoelectric focusing and molecular analysis. Results were consistent with the presence of a pI 8.6 ESBL active on cefotaxime, ceftazidime, cefepime, and aztreonam. Mating experiments showed that the CTX-M-1 determinant was transferable. To the best of our knowledge, this is the first report of CTX–M-1 type ESBL in Salmonella serovar Bovismorbificans.

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Published In

cover image Microbial Drug Resistance
Microbial Drug Resistance
Volume 13Issue Number 2June 2007
Pages: 124 - 129
PubMed: 17650965

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Published online: 25 July 2007
Published in print: June 2007

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Rosa Monno
Department of Internal Medicine and Public Health, University of Bari, I 70124 Bari, Italy.
Caterina Rizzo
Department of Pharmacobiological Sciences, University of Bari, I 70124 Bari, Italy.
Danila De Vito
Department of Odontostomatology and Surgery, University of Bari, I 70124 Bari, Italy.
Elisabetta Nucleo
Department of Morphological, Eidological and Clinical Sciences, University of Pavia, I-27100 Pavia, Italy.
Roberta Migliavacca
Department of Morphological, Eidological and Clinical Sciences, University of Pavia, I-27100 Pavia, Italy.
Laura Pagani
Department of Morphological, Eidological and Clinical Sciences, University of Pavia, I-27100 Pavia, Italy.
Giovanni Rizzo
Department of Internal Medicine and Public Health, University of Bari, I 70124 Bari, Italy.

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