The Effects of Intermittent Fasting on Glycemic Control and Body Composition in Adults with Obesity and Type 2 Diabetes: A Systematic Review
Publication: Metabolic Syndrome and Related Disorders
Volume 18, Issue Number 10
Abstract
The purpose of this study was to evaluate the effects of intermittent fasting on glycemic control and body composition in adults with obesity and type 2 diabetes. Although intermittent fasting has shown some promise in improving glucoregulatory indicators and body composition in adults with obesity, there is currently no systematic review evaluating these effects in adults with obesity and type 2 diabetes. A database search of PubMed, CINHAL, and MEDLINE identified five studies that met inclusion criterion. All studies were randomized controlled trials in adult subjects (n = 46–137) with type 2 diabetes and a body mass index of ≥30 kg/m2. Four different intermittent fasting regimens were reviewed. All fasting regimens revealed strong evidence to support intermittent fasting as a feasible diet to improve glycemia and body composition measures within 12–24 weeks. Follow-up 12–18 months after intermittent fasting did not show promising results for continued weight loss and improved glycemic control. The majority of the studies demonstrated insignificant differences between intermittent fasting and continuous energy restriction for measures of glycated hemoglobin a1c and body composition. More data on intermittent fasting in adults with obesity and type 2 diabetes are needed to determine its benefits within this patient population. Future research should include consistent fasting regimens and larger sample sizes to improve the reliability and generalizability of the data. Also, consistent follow-up after a fasting intervention may enhance long-term benefits and should be considered in future research.
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Published In
Metabolic Syndrome and Related Disorders
Volume 18 • Issue Number 10 • December 2020
Pages: 450 - 461
PubMed: 32780629
Copyright
Copyright 2020, Mary Ann Liebert, Inc., publishers.
History
Published in print: December 2020
Published online: 24 November 2020
Published ahead of print: 11 August 2020
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No conflicting financial interests exist.
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