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Published Online: 9 November 2004

A Review and Rationale for the Use of Cellular Transplantation as a Therapeutic Strategy for Traumatic Brain Injury

Publication: Journal of Neurotrauma
Volume 21, Issue Number 11

Abstract

Experimental research during the past decade has greatly increased our understanding of the pathophysiology of traumatic brain injury (TBI) and allowed us to develop neuroprotective pharmacological therapies. Encouraging results of experimental pharmacological interventions, however, have not been translated into successful clinical trials, to date. Traumatic brain injury is now believed to be a progressive degenerative disease characterized by cell loss. The limited capacity for self-repair of the brain suggests that functional recovery following TBI is likely to require cellular transplantation of exogenous cells to replace those lost to trauma. Recent advances in central nervous system transplantation techniques involve technical and experimental refinements and the analysis of the feasibility and efficacy of transplantation of a range of stem cells, progenitor cells and postmitotic cells. Cellular transplantation has begun to be evaluated in several models of experimental TBI, with promising results. The following is a compendium of these new and exciting studies, including a critical discussion of the rationale and caveats associated with cellular transplantation techniques in experimental TBI research. Further refinements in future research are likely to improve results from transplantation-based treatments for TBI.

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cover image Journal of Neurotrauma
Journal of Neurotrauma
Volume 21Issue Number 11November 2004
Pages: 1501 - 1538
PubMed: 15684646

History

Published online: 9 November 2004
Published in print: November 2004

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Joost W. Schouten
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Carl T. Fulp
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.
Nicolas C. Royo
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Kathryn E. Saatman
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Deborah J. Watson
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Evan Y. Snyder
Program in Developmental and Regenerative Cell Biology, The Burnham Institute, La Jolla, California.
John Q. Trojanowski
The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Darwin J. Prockop
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana.
Andrew I.R. Maas
Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Tracy K. McIntosh
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.

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