Research Article
No access
Published Online: 28 June 2007

Locomotor Ability in Spinal Rats Is Dependent on the Amount of Activity Imposed on the Hindlimbs during Treadmill Training

Publication: Journal of Neurotrauma
Volume 24, Issue Number 6

Abstract

Studies have shown that treadmill training with body weight support is effective for enhancing locomotor recovery following a complete spinal cord transection (ST) in animals. However, there have been no studies that have investigated the extent that functional recovery in ST animals is dependent on the amount of activity imposed on the hindlimbs during training. In rats transected as neonates (P5), we used a robotic device to impose either a high or a low amount of hindlimb activity during treadmill training starting 23 days after transection. The rats were trained 5 days per week for 4 weeks. One group (n = 13) received 1000 steps/training session and a second group (n = 13) received 100 steps/training session. During training, the robotic device imposed the maximum amount of weight that each rat could bear on the hindlimbs, and counted the number of stepping movements during each session. After 4 weeks of training, the number of steps performed during treadmill testing was not significantly different between the two groups. However, the quality of stepping in the group that received 1000 steps/training session improved over a range of levels of weight bearing on the hindlimbs and at different treadmill speeds. In contrast, little improvement in the quality of stepping was observed in the group that received only 100 steps/training session. These findings indicate that the ability of the lumbar spinal cord to adjust to load- and speed-related sensory stimuli associated with stepping is dependent on the number of repetitions of the same activity that is imposed on the spinal circuits during treadmill training.

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

cover image Journal of Neurotrauma
Journal of Neurotrauma
Volume 24Issue Number 6June 2007
Pages: 1000 - 1012
PubMed: 17600516

History

Published online: 28 June 2007
Published in print: June 2007

Permissions

Request permissions for this article.

Topics

Authors

Affiliations

John Cha
Department of Biological Science, California State University, Los Angeles, California.
Chad Heng
Department of Biological Science, California State University, Los Angeles, California.
David J. Reinkensmeyer
Department of Mechanical and Aerospace Engineering, University of California, Irvine, California.
Roland R. Roy
Brain Research Institute, UCLA, Los Angeles, California.
V. Reggie Edgerton
Brain Research Institute, UCLA, Los Angeles, California.
Department of Physiological Science, and Neurobiology, UCLA, Los Angeles, California.
Ray D. De Leon
School of Kinesiology and Nutritional Science, California State University, Los Angeles, California.

Metrics & Citations

Metrics

Citations

Export citation

Select the format you want to export the citations of this publication.

View Options

Get Access

Access content

To read the fulltext, please use one of the options below to sign in or purchase access.

Society Access

If you are a member of a society that has access to this content please log in via your society website and then return to this publication.

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

View options

PDF/EPUB

View PDF/ePub

Media

Figures

Other

Tables

Share

Share

Copy the content Link

Share on social media

Back to Top