Case Report
No access
Published Online: 17 March 2022

Reversal of Acquired Prosopagnosia Using Quantitative Electroencephalography-Guided Laser Therapy

Publication: Photobiomodulation, Photomedicine, and Laser Surgery
Volume 40, Issue Number 3

Abstract

Background: Currently treatment for prosopagnosia is limited.
Methods: We report the reversal of acquired associative-type prosopagnosia (AAP) using quantitative electroencephalography (qEEG)-guided transcranial laser therapy (qGLT) in a subject with temporal lobe epilepsy (TLE) and mild cognitive impairment (MCI).
Results: Objective and subjective measures of improvement in AAP, TLE, and MCI are presented. Additional improvement, measured through qEEG, was found 1-month post-treatment.
Conclusions: There was no recurrence of AAP for 1 year. We conclude that further research into the utility of qGLT in the treatment of AAP is warranted.

Get full access to this article

View all available purchase options and get full access to this article.

References

1. Barton JJ. Structure and function in acquired prosopagnosia: lessons from a series of 10 patients with brain damage. J Neuropsychol 2008;2:197–225.
2. DeGutis JM, Chiu C, Grosso ME, Cohan S. Face processing improvements in prosopagnosia: successes and failures over the last 50 years. Front Hum Neurosci 2014;8:561.
3. Corrow SL, Dalrymple KA, Barton JJ. Prosopagnosia: current perspectives. Eye Brain 2016;8:165–175.
4. Bate S, Bennetts RJ. The rehabilitation of face recognition impairments: a critical review and future directions. Front Hum Neurosci 2014;8:491.
5. DeGutis JM, Cohan S, Alexander DK, Aguirre GK, Nakayama K, editors. Facial expression training improves emotion recognition and changes neural tuning in a patient with acquired emotion recognition deficits and prosopagnosia. Vision Sciences Society Annual Meeting, Naples, Florida, 2013.
6. Davies-Thompson J, Fletcher K, Hills C, Pancaroglu R, Corrow SL, Barton JJ. Perceptual learning of faces: a rehabilitative study of acquired prosopagnosia. J Cogn Neurosci 2017;29:573–591.
7. Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant improvement in cognition in mild to moderately severe dementia cases treated with transcranial plus intranasal photobiomodulation: case series report. Photomed Laser Surg 2017;35:432–441.
8. Berman MH, Halper JP, Nichols TW, Jarrett H, Lundy A, Huang JH. Photobiomodulation with near infrared light helmet in a pilot, placebo controlled clinical trial in dementia patients testing memory and cognition. J Neurol Neurosci 2017;8:176.
9. Zomorrodi R, Saltmarche, A.E., Loheswaran, G., Ho, K.F. and Lim, L., eds. Complementary EEG evidence for a significantly improved Alzheimer's disease case after photobiomodulation treatment. 26th Annual Scientific Conference, Canadian Academy of Geriatric Psychiatry, Toronto, 2017.
10. Chao LL. Effects of home photobiomodulation treatments on cognitive and behavioral function, cerebral perfusion, and resting-state functional connectivity in patients with dementia: a pilot trial. Photobiomodul Photomed Laser Surg 2019;37:133–141.
11. Santos L, Olmo-Aguado SD, Valenzuela PL, et al. Photobiomodulation in Parkinson's disease: a randomized controlled trial. Brain Stimul 2019;12:810–812.
12. das Neves MF, Aleixo DC, Mendes IS, et al. Long-term analyses of spastic muscle behavior in chronic poststroke patients after near-infrared low-level laser therapy (808 nm): a double-blinded placebo-controlled clinical trial. Lasers Med Sci 2020;35:1459–1467.
13. Morries LD, Cassano P, Henderson TA. Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy. Neuropsychiatr Dis Treat 2015;11:2159–2175.
14. Yao X, Liu C, Feng D, Yin J, Chen G. Transcranial near-infrared laser therapy in improving cognitive recovery of function following traumatic brain injury. Curr Neuropharmacol 2018;16:1320–1326.
15. Henderson TA, Morries LD. SPECT perfusion imaging demonstrates improvement of traumatic brain injury with transcranial near-infrared laser phototherapy. Adv Mind Body Med 2015;29:27–33.
16. Naeser MA, Hamblin MR. Traumatic brain injury: a major medical problem that could be treated using transcranial, red/near-infrared LED photobiomodulation. Photomed Laser Surg 2015;33:443–446.
17. Lapchak PA, Boitano PD, Butte PV, et al. Transcranial near-infrared laser transmission (NILT) profiles (800 nm): systematic comparison in four common research species. PLoS One 2015;10:e0127580.
18. Henderson TA, Morries LD. Multi-watt near-infrared phototherapy for the treatment of comorbid depression: an open-label single-arm study. Front Psychiatry 2017;8:187.
19. Naeser MA, Zafonte R, Krengel MH, et al. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. J Neurotrauma 2014;31:1008–1017.
20. Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B 1999;49:1–17.
21. Serrage H, Heiskanen V, Palin WM, et al. Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light. Photochem Photobiol Sci 2019;18:1877–1909.
22. Blonz ER. Alzheimer's disease as the product of a progressive energy deficiency syndrome in the Central Nervous System: the neuroenergetic hypothesis. J Alzheimers Dis 2017;60:1223–1229.
23. Tedford CE, DeLapp S, Jacques S, Anders J. Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue. Lasers Surg Med 2015;47:312–322.
24. Henderson TA, Morries LD. Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain? Neuropsychiatr Dis Treat 2015;11:2191–2208.
25. Luo M, Zhou XH, Zou T, Keyim K, Dong LM. Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment. Genet Mol Res 2015;14:5407–5416.
26. Thatcher RW. Handbook of Quantitative Electroencephalography and EEG Biofeedback. St. Petersburg, FL: Anipublishing, 2012.
27. Technologies TC. Cortical Functions, McLean Hospital, Harvard Medical School, Wellesley College. Available at: testmybrain.org. 2012.
28. Duchaine B, Nakayama K. The Cambridge Face Memory Test: results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants. Neuropsychologia 2006;44:576–585.

Information & Authors

Information

Published In

cover image Photobiomodulation, Photomedicine, and Laser Surgery
Photobiomodulation, Photomedicine, and Laser Surgery
Volume 40Issue Number 3March 2022
Pages: 205 - 210
PubMed: 34981964

History

Published online: 17 March 2022
Published in print: March 2022
Published ahead of print: 4 January 2022
Accepted: 4 October 2021
Received: 15 April 2021

Permissions

Request permissions for this article.

Topics

    Authors

    Affiliations

    The Whole Psychiatry & Brain Recovery Center, Institute for Functional Medicine, Georgetown University School of Medicine, Rockville, Maryland, and Washington, DC, USA.
    Joel Lubar
    Southeastern Neurofeedback Institute, Inc., Professor Emeritus University of Tennessee, Pompano Beach, Florida, USA.

    Notes

    Address correspondence to: Robert Hedaya, MD, The Whole Psychiatry & Brain Recovery Center, Institute for Functional Medicine, Georgetown University School of Medicine, Rockville, MD, USA [email protected]

    Authors’ Contributions

    R.H. collected patient information, conceptualized, designed, and performed treatment interventions based on qEEG analysis, performed laboratory testing, and drafted the article. J.L. assisted with data analysis and figures. All authors have seen and approved this article.

    Author Disclosure Statement

    No competing financial interests exist. The methodology is patent pending.

    Funding Information

    There was no funding received for this study. Aspen Laser provided the laser.

    Ethics Statement

    This study was carried out with the informed consent of the patient regarding the experimental nature of the treatment. Clinical data in this case report were collected in the normal course of treatment. Written consent from the patient was given for the publication of this case report.

    Metrics & Citations

    Metrics

    Citations

    Export citation

    Select the format you want to export the citations of this publication.

    View Options

    Get Access

    Access content

    To read the fulltext, please use one of the options below to sign in or purchase access.

    Society Access

    If you are a member of a society that has access to this content please log in via your society website and then return to this publication.

    Restore your content access

    Enter your email address to restore your content access:

    Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

    View options

    PDF/EPUB

    View PDF/ePub

    Full Text

    View Full Text

    Media

    Figures

    Other

    Tables

    Share

    Share

    Copy the content Link

    Share on social media

    Back to Top