Research Article
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Published Online: 15 February 2008

Zinc Supplementation in the Elderly Reduces Spontaneous Inflammatory Cytokine Release and Restores T Cell Functions

Publication: Rejuvenation Research
Volume 11, Issue Number 1

ABSTRACT

Aging is associated with low-grade inflammation on the one hand and mild zinc deficiency on the other. These conditions contribute to decreased immune functions, resulting in increased incidences of infections and autoimmune diseases. The aim of this study was to give more insight into the question, to what extent is low-grade inflammation caused by zinc deficient status. Here we report the effect of improved intracellular zinc status on low-grade inflammatory activity in 19 healthy elderly subjects. Our experiments show that adjustment of labile zinc by moderate zinc supplementation reduces spontaneous cytokine release and defects in termination of inflammatory activity. This results in reduced amounts of unspecific preactivated T cells and leads to improved T cell response upon mitogenic stimulation. Therefore, in contrast to other anti-inflammatory drugs, zinc does not suppress, but improves immune reaction upon pathogen invasion. These results suggest that mildly zinc-deficient, healthy elderly subjects might benefit from moderate zinc supplementation due to a more balanced immune response with reduced incidences of infections and autoimmune diseases.

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Published In

cover image Rejuvenation Research
Rejuvenation Research
Volume 11Issue Number 1February 2008
Pages: 227 - 237
PubMed: 18279033

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Published online: 15 February 2008
Published in print: February 2008

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Laura Kahmann
Institute of Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Peter Uciechowski
Institute of Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Sabine Warmuth
University Employee Health Office, RWTH Aachen University Hospital, Aachen, Germany.
Birgit Plümäkers
Institute of Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Axel M. Gressner
Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Aachen, Germany.
Marco Malavolta
Immunology Centre, Nutrition, Immunity, and Aging Section, Research Department, INRCA, Ancona, Italy.
Eugenio Mocchegiani
Immunology Centre, Nutrition, Immunity, and Aging Section, Research Department, INRCA, Ancona, Italy.
Lothar Rink
Institute of Immunology, RWTH Aachen University Hospital, Aachen, Germany.

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