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Published Online: 6 May 2009

Characteristics, Formation, and Pathophysiology of Glucosepane: A Major Protein Cross-Link

Publication: Rejuvenation Research
Volume 12, Issue Number 2

Abstract

Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has been shown to accumulate in the extracellular matrix, where it cross-links collagen. Levels of glucosepane increase with aging. By increasing collagen stiffness, glucosepane cross-links may have significant implications in several age-related diseases, such as cardiovascular disease, diabetes, and osteoporosis. Although the formation pathways for glucosepane are relatively well researched, much is still unknown about the accumulation and pathophysiology of glucosepane.

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cover image Rejuvenation Research
Rejuvenation Research
Volume 12Issue Number 2April 2009
Pages: 137 - 148
PubMed: 19415980

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Published online: 6 May 2009
Published in print: April 2009

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Johan Svantesson Sjöberg
Lund University, Lund, Sweden.
Sven Bulterijs
Ghent University, Ghent, Belgium.

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