The Role of NMDA Receptors in Neural Stem Cell Proliferation and Differentiation
Publication: Stem Cells and Development
Volume 26, Issue Number 11
Abstract
N-methyl-d-aspartate receptors (NMDARs) are expressed abundantly in the brain and play an important role in the regulation of neuronal development, learning, memory, neurodegenerative diseases, and neurogenesis, all of which are extensively discussed in reviews published elsewhere. While the number of research articles on the developmental and neurological cues that trigger NMDAR localization across a developing neuron and the role of the NMDAR in embryonic and adult stem cell proliferation and differentiation have been growing dramatically over the past few years, there is not a single review on this latter general topic. In the proposed review, we will summarize the current understanding of NMDARs in stem cell biology and their involvement in pathophysiological processes of neuron development, especially during early neuronal development (immature neurons) and differentiation.
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Published In
Stem Cells and Development
Volume 26 • Issue Number 11 • June 1, 2017
Pages: 798 - 807
PubMed: 28381110
Copyright
Copyright 2017, Mary Ann Liebert, Inc.
History
Published in print: June 1, 2017
Published online: 1 June 2017
Published ahead of print: 10 May 2017
Published ahead of production: 5 April 2017
Accepted: 5 April 2017
Received: 15 November 2016
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No competing financial interests exist.
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