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Published Online: 4 February 2009

Biological Basis of Bone Formation, Remodeling, and Repair—Part II: Extracellular Matrix

Publication: Tissue Engineering Part B: Reviews
Volume 14, Issue Number 3

Abstract

The bony biochemical environment is a complex system that permits and promotes cellular functions that lead to matrix production and ossification. In Part I of this review, we discussed the important actions of signaling molecules, including hormones, cytokines, and growth factors. Here, we review other constituents of the extracellular matrix, including minerals, fibrinous and nonfibrinous proteins, and enzymes such as the matrix metalloproteinases. We conclude with a discussion of the role of biochemical modulation in endogenous and exogenous tissue engineering.

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Published In

cover image Tissue Engineering Part B: Reviews
Tissue Engineering Part B: Reviews
Volume 14Issue Number 3September 2008
Pages: 275 - 283
PubMed: 19183102

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Published online: 4 February 2009
Published in print: September 2008

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Alexander C. Allori
Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, New York.
Alexander M. Sailon
Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, New York.
Stephen M. Warren
Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, New York.

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