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Published Online: 12 December 2011

Fabrication of Large Pores in Electrospun Nanofibrous Scaffolds for Cellular Infiltration: A Review

Publication: Tissue Engineering Part B: Reviews
Volume 18, Issue Number 2

Abstract

In the past decade, considerable effort has been made to construct biomimetic scaffolds from electrospun nanofibers for engineering different tissues. However, one of the major concerns with electrospun nanofibrous scaffolds is that the densely arranged architecture of fibers and small pores or voids between fibers hinder efficient cellular infiltration or prevent three dimensional (3D) cellular integration with host tissue in vivo after implantation. To overcome this problem, many concepts or strategies applicable during the electrospinning or post-electrospinning procedures have been proposed to enlarge pore size of electrospun scaffolds. This article addresses the issues of pore geometry and cellular infiltration of electrospun scaffolds, and first reviews the fabrication solutions/approaches applied to achieve larger micropores in electrospun mats. The evidence and potential for fostering cellular infiltration using these improved porous scaffolds are then discussed. Finally, it is hoped that this will enable us to better exploit viable technologies or develop new ones for constructing ideal nanofibrous architecture for fulfilling specific tissue engineering needs.

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cover image Tissue Engineering Part B: Reviews
Tissue Engineering Part B: Reviews
Volume 18Issue Number 2April 2012
Pages: 77 - 87
PubMed: 21902623

History

Published in print: April 2012
Published ahead of print: 14 December 2011
Published online: 12 December 2011
Published ahead of production: 9 September 2011
Accepted: 8 September 2011
Received: 11 July 2011

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Shaoping Zhong
Department of Bioengineering, National University of Singapore, Singapore.
Yanzhong Zhang
Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P.R. China.
Chwee Teck Lim
Department of Bioengineering, National University of Singapore, Singapore.
Department of Mechanical Engineering, National University of Singapore, Singapore.
Mechanobiology Institute, National University of Singapore, Singapore.

Notes

Address correspondence to:Chwee Teck LimDepartment of BioengineeringNational University of Singapore9 Engineering Drive 1Singapore 117576Singapore
E-mail: [email protected]

Disclosure Statement

No competing financial interests exist.

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