Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications
Publication: Tissue Engineering Part B: Reviews
Volume 23, Issue Number 1
Abstract
The development of molecularly imprinted polymers (MIPs) using biocompatible production methods enables the possibility to further exploit this technology for biomedical applications. Tissue engineering (TE) approaches use the knowledge of the wound healing process to design scaffolds capable of modulating cell behavior and promote tissue regeneration. Biomacromolecules bear great interest for TE, together with the established recognition of the extracellular matrix, as an important source of signals to cells, both promoting cell–cell and cell–matrix interactions during the healing process. This review focuses on exploring the potential of protein molecular imprinting to create bioactive scaffolds with molecular recognition for TE applications based on the most recent approaches in the field of molecular imprinting of macromolecules. Considerations regarding essential components of molecular imprinting technology will be addressed for TE purposes. Molecular imprinting of biocompatible hydrogels, namely based on natural polymers, is also reviewed here. Hydrogel scaffolds with molecular memory show great promise for regenerative therapies. The first molecular imprinting studies analyzing cell adhesion report promising results with potential applications for cell culture systems, or biomaterials for implantation with the capability for cell recruitment by selectively adsorbing desired molecules.
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Information & Authors
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Published In
Tissue Engineering Part B: Reviews
Volume 23 • Issue Number 1 • February 2017
Pages: 27 - 43
PubMed: 27484808
Copyright
Copyright 2017, Mary Ann Liebert, Inc.
History
Published in print: February 2017
Published online: 1 February 2017
Published ahead of print: 31 August 2016
Published ahead of production: 2 August 2016
Accepted: 21 July 2016
Received: 14 May 2016
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