The Role of Myeloid-Derived Suppressor Cells in Viral Infection
Abstract
Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that are well described as potent immune regulatory cells during human cancer and murine tumor models. Reports of MDSCs during viral infections remain limited, and their association with immunomodulation of viral diseases is still being defined. Here, we provide an overview of MDSCs or MDSC-like cells identified during viral infections, including murine viral models and human viral diseases. Understanding the similarities and/or differences of virally induced versus tumor-derived MDSCs will be important for designing future immunotherapeutic approaches.
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Copyright 2017, Mary Ann Liebert, Inc.
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Published in print: March 2017
Published online: 1 March 2017
Published ahead of print: 4 January 2017
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