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Published Online: 6 June 2024

Association of Interleukin-6 (rs1800795) and Interleukin-10 (rs1800896) Genetic Polymorphisms with the Outcome of COVID-19 Infection: A Single Center Study

Publication: Viral Immunology

Abstract

The corona virus disease-2019 (COVID-19) pandemic has affected most of the world with varying degrees of morbidity and mortality. The presence of genetic polymorphisms may be associated with the severity and outcome of COVID-19 infection. This work aimed to evaluate the genetic polymorphisms of interleukin (IL-6) and IL-10 genes with the outcome of COVID-19 infection. This cross-sectional study was conducted on 354 patients who were classified into moderate and severe cases (including alive and deceased cases). All individuals were genotyped for one SNP for IL-6 (rs1800795) and one SNP for IL10 (rs1800896) using allelic discrimination real-time PCR technique. In this study, 198 cases were moderate, and 156 cases were severe. The risk of allele carriage of the minor allele of IL-6 rs1800795 (C) was significantly higher among the severe group when compared with that of the moderate group (p < 0.0001), while there was a mild significant difference of same allele carriage among alive cases when compared to that of deceased one (p < 0.04). Furthermore, the risk of the C allele of IL-10 rs1800896 was significantly increased in severe cases when compared with the moderate group (p < 0.0001), while there was no significant difference of the risk of the C allele in deceased cases when compared with that of alive ones (p > 0.05). In conclusion, the C allele (rs1800795) of IL-6 and the C allele (rs1800896) of IL-10 were highly significant in severe cases than in moderate cases. The C allele carriage of IL-6 showed only a significant difference between alive and deceased patients and not with the C allele of IL-10.

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Information & Authors

Information

Published In

cover image Viral Immunology
Viral Immunology

History

Published online: 6 June 2024

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Data Availability

The datasets used and analyzed during this work are available from the corresponding author upon reasonable request.

Authors

Affiliations

Tropical Medicine and Hepatogastroenterology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Molecular Genetic Unit of Endemic Hepatogastroenterology and Infectious Diseases (MGUHID), Mansoura University, Mansoura, Egypt.
Mustafa Naemattalah
Molecular Genetic Unit of Endemic Hepatogastroenterology and Infectious Diseases (MGUHID), Mansoura University, Mansoura, Egypt.
Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hatem Elalfy
Tropical Medicine and Hepatogastroenterology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Molecular Genetic Unit of Endemic Hepatogastroenterology and Infectious Diseases (MGUHID), Mansoura University, Mansoura, Egypt.
Ahmed Elhawary
Tropical Medicine and Hepatogastroenterology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abdel-Hady El-Gilany
Public Health Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hosam Zaghloul
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Sara Anber
Molecular Genetic Unit of Endemic Hepatogastroenterology and Infectious Diseases (MGUHID), Mansoura University, Mansoura, Egypt.
Biochemistry, Mansoura University, Mansoura, Egypt.
Mohamed Elegezy
Tropical Medicine and Hepatogastroenterology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Notes

Address correspondence to: Dr. Mahmoud El-Bendary, Tropical Medicine and Hepatogastroenterology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35111, Egypt [email protected] [email protected]

Authors Contributions

M.B. and M.N. were involved in study conception and design. M.B. wrote the article. A.G. acquired, analyzed and interpreted the data. M.N., H.Z., and S.A. performed laboratory and molecular genetic study. H.E., A.H., and M.E. contribute in the recruitment of cases and their clinical diagnosis. All authors were involved in the drafting and critical revision of the article. All authors approved the final version of the article.

Author Disclosure Statement

The authors declare that they have no competing interests.

Funding Information

This research was funded by Mansoura Research Unit-competitive funding projects, Graduate Studies Research and Cultural Affairs, Mansoura University, Egypt.

Ethical Approval and Consent to Participate

The Institutional Review Board of Mansoura Faculty of Medicine approved this study, and written informed consent was obtained from all patients. All experimental procedure complied with the Declaration of Helsinki.

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