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Published Online: 7 July 2004

Antioxidant Action of Moringa oleifera Lam. (Drumstick) Against Antitubercular Drugs Induced Lipid Peroxidation in Rats

Publication: Journal of Medicinal Food
Volume 6, Issue Number 3

Abstract

The protective effect of Moringa oleifera Lam. (Moringaceae) on hepatic marker enzymes, lipid peroxidation, and antioxidants was investigated during antitubercular drug (isoniazid, rifampicin, and pyrazinamide)-induced toxicity in rats. Enhanced hepatic marker enzymes and lipid peroxidation of antitubercular drug treatment was accompanied by a significant decrease in the levels of vitamin C, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase. Administration of Moringa oleifera extract and silymarin significantly decreased hepatic marker enzymes and lipid peroxidation with a simultaneous increase in the level of antioxidants. We speculate that Moringa oleifera extract exerts its protective effects by decreasing liver lipid peroxides and enhancing antioxidants.

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cover image Journal of Medicinal Food
Journal of Medicinal Food
Volume 6Issue Number 3October 2003
Pages: 255 - 259
PubMed: 14585192

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Published online: 7 July 2004
Published in print: October 2003

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N. Ashok Kumar
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India
L. Pari
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India

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